| Autor: |
Chen F, Onkar S, Zou J, Li Y, Arbore H, Maley S, Tseng G, Lucas P, Bruno T, Vignali D, Foldi J, Balic M, Lee A, Oesterreich S |
| Jazyk: |
angličtina |
| Zdroj: |
Research square [Res Sq] 2024 Aug 13. Date of Electronic Publication: 2024 Aug 13. |
| DOI: |
10.21203/rs.3.rs-4579052/v1 |
| Abstrakt: |
Understanding interplay of breast cancer and microenvironment is critical. Here, we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER+/HER2- invasive lobular breast cancers. The proliferative subtype associated with increased immune infiltration especially by immunosuppressive regulatory T-cells and macrophages. We also defined a TAM-Low signature, which associated with lower infiltration of proliferative, pro-inflammatory TAM, and improved outcome in patients with ER+ tumors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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