Alterations in plasma proteome during acute COVID-19 and recovery.

Autor: Suski M; Department of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka str, Kraków, 31 531, Poland. maciej.suski@uj.edu.pl., Olszanecka A; Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, 2 Jakubowskiego str, Kraków, 30-688, Poland.; University Hospital in Kraków, 2 Jakubowskiego str, Kraków, 30-688, Poland., Stachowicz A; Department of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka str, Kraków, 31 531, Poland., Kiepura A; Department of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka str, Kraków, 31 531, Poland., Terlecki M; Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, 2 Jakubowskiego str, Kraków, 30-688, Poland.; University Hospital in Kraków, 2 Jakubowskiego str, Kraków, 30-688, Poland., Madej J; Department of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka str, Kraków, 31 531, Poland., Rajzer M; Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, 2 Jakubowskiego str, Kraków, 30-688, Poland.; University Hospital in Kraków, 2 Jakubowskiego str, Kraków, 30-688, Poland., Olszanecki R; Department of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka str, Kraków, 31 531, Poland.
Jazyk: angličtina
Zdroj: Molecular medicine (Cambridge, Mass.) [Mol Med] 2024 Aug 25; Vol. 30 (1), pp. 131. Date of Electronic Publication: 2024 Aug 25.
DOI: 10.1186/s10020-024-00898-5
Abstrakt: Background: The severe course of COVID-19 causes cardiovascular injuries, although the mechanisms involved are still not fully recognized, linked, and understood. Their characterization is of great importance with the establishment of the conception of post-acute sequelae of COVID-19, referred to as long COVID, where blood clotting and endothelial abnormalities are believed to be the key pathomechanisms driving circulatory system impairment.
Methods: The presented study investigates temporal changes in plasma proteins in COVID-19 patients during hospitalization due to SARS-CoV-2 infection and six months after recovery by targeted SureQuant acquisition using PQ500 panel.
Results: In total, we identified 167 proteins that were differentially regulated between follow-up and hospitalization, which functionally aggregated into immune system activation, complement and coagulation cascades, interleukins signalling, platelet activation, and extracellular matrix organization. Furthermore, we found that temporal quantitative changes in acute phase proteins correlate with selected clinical characteristics of COVID-19 patients.
Conclusions: In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.
(© 2024. The Author(s).)
Databáze: MEDLINE
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