Combination of High-Dose Daptomycin and Ceftriaxone for Cardiac Implantable Electronic Device Infections: A 10-Year Experience.

Autor: Ponta G; San Raffaele Vita-Salute University, Milan, Italy; IRCCS San Raffaele Scientific Institute, Department of Infectious Diseases, Milan, Italy., Ranzenigo M; San Raffaele Vita-Salute University, Milan, Italy; IRCCS San Raffaele Scientific Institute, Department of Infectious Diseases, Milan, Italy., Marzi A; IRCCS San Raffaele Scientific Institute, Department of Cardiac Electrophysiology, Milan, Italy., Oltolini C; IRCCS San Raffaele Scientific Institute, Department of Infectious Diseases, Milan, Italy., Tassan Din C; IRCCS San Raffaele Scientific Institute, Department of Infectious Diseases, Milan, Italy., Uberti-Foppa C; San Raffaele Vita-Salute University, Milan, Italy; IRCCS San Raffaele Scientific Institute, Department of Infectious Diseases, Milan, Italy., Spagnuolo V; IRCCS San Raffaele Scientific Institute, Department of Infectious Diseases, Milan, Italy., Mazzone P; IRCCS San Raffaele Scientific Institute, Department of Cardiac Electrophysiology, Milan, Italy., Della Bella P; IRCCS San Raffaele Scientific Institute, Department of Cardiac Electrophysiology, Milan, Italy., Scarpellini P; IRCCS San Raffaele Scientific Institute, Department of Infectious Diseases, Milan, Italy., Castagna A; San Raffaele Vita-Salute University, Milan, Italy; IRCCS San Raffaele Scientific Institute, Department of Infectious Diseases, Milan, Italy., Ripa M; San Raffaele Vita-Salute University, Milan, Italy; IRCCS San Raffaele Scientific Institute, Department of Infectious Diseases, Milan, Italy. Electronic address: ripa.marco@hsr.it.
Jazyk: angličtina
Zdroj: Clinical therapeutics [Clin Ther] 2024 Oct; Vol. 46 (10), pp. 819-821. Date of Electronic Publication: 2024 Aug 24.
DOI: 10.1016/j.clinthera.2024.07.012
Abstrakt: Purpose: Cardiac implantable electronic device (CIED) infections are increasingly common. Gram-positive bacteria such as coagulase negative staphylococci and Staphylococcus aureus are the most commonly involved pathogens. The aim of this study was to describe the characteristics and outcome of patients with CIED infections who underwent device removal and were empirically treated with high dose (8-12 mg/kg daily) daptomycin (DAP) in combination with ceftriaxone (CRO).
Methods: Retrospective, single center study including patients admitted at IRCCS San Raffaele Hospital (Milan, Italy), from June 2011 to June 2021, who underwent device removal for CIED infection and were empirically treated with DAP/CRO.
Findings: Overall, 147 patients were included in this study. Median duration of therapy was 16 days (IQR 14-26). Empirical treatment with DAP/CRO was confirmed as definitive treatment in 140 patients (95.2%). In 7 (4.8%) patients DAP/CRO were discontinued according to the definite microbiological isolates: Corynebacterium spp. (4), Pseudomonas aeruginosa (2), Enterobacter cloacae (1). Ten patients (6.8%) underwent treatment simplification to narrow-spectrum antibiotics. One patient (0.6%) interrupted DAP-CRO due to pancytopenia. 6-month follow-up was available for 123/147 patients (83.7%): 9 patients recurred with a CIED infection (7.3%), and 9 died (7.3%).
Implications: In our 10-year experience, high-dose DAP in combination with CRO represented a good option for empirical therapy of CIED infections. DAP-CRO combination was safe and effective, showing no significant drug-related adverse events and low rates of 6-month recurrence and mortality.
Competing Interests: Declaration of competing interest The authors have no relevant financial or non-financial interests to disclose.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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