Bioaccessibility and bioavailability of Pb and Cd in rice is affected by propolis and its extracts and Fe intervention.

Autor: Zhuang P; Guangdong Provincial Key Laboratory of Applied Botany, Xiaoliang Research Station of Tropical Coastal Ecosystems, Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems, the CAS Engineering Laboratory for Ecological Restoration of Island and Coastal Ecosystems, and South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, PR China; South China National Botanical Garden, Guangzhou 510650, PR China. Electronic address: zhuangp@scbg.ac.cn., Chen X; Guangdong Provincial Key Laboratory of Applied Botany, Xiaoliang Research Station of Tropical Coastal Ecosystems, Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems, the CAS Engineering Laboratory for Ecological Restoration of Island and Coastal Ecosystems, and South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, PR China; University of Chinese Academy of Sciences, Beijing 100049, China., Sun S; Guangdong Provincial Key Laboratory of Applied Botany, Xiaoliang Research Station of Tropical Coastal Ecosystems, Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems, the CAS Engineering Laboratory for Ecological Restoration of Island and Coastal Ecosystems, and South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, PR China; University of Chinese Academy of Sciences, Beijing 100049, China., Li Y; Guangdong Provincial Key Laboratory of Applied Botany, Xiaoliang Research Station of Tropical Coastal Ecosystems, Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems, the CAS Engineering Laboratory for Ecological Restoration of Island and Coastal Ecosystems, and South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, PR China; South China National Botanical Garden, Guangzhou 510650, PR China., Mo H; Guangdong Provincial Key Laboratory of Applied Botany, Xiaoliang Research Station of Tropical Coastal Ecosystems, Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems, the CAS Engineering Laboratory for Ecological Restoration of Island and Coastal Ecosystems, and South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, PR China; South China National Botanical Garden, Guangzhou 510650, PR China.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2024 Nov 15; Vol. 951, pp. 175697. Date of Electronic Publication: 2024 Aug 23.
DOI: 10.1016/j.scitotenv.2024.175697
Abstrakt: Increasing the intake of dietary supplements containing antioxidant components can reduce the oral bioavailability of lead (Pb) and cadmium (Cd) and benefit human health. In this study, the effects of propolis and its extracts (kaempferol (KAE), quercetin (QR), and caffeic acid phenethyl ester (CAPE)) in conjunction with proanthocyanidins (PA) on Pb and Cd bioaccessibility (BAC) and the relative bioavailability (RBA) in brown and polished rice are investigated. The results of in vitro tests showed that propolis and its extracts were effective in reducing Pb BAC in both brown and polished rice. A medium dose of PA had a significant reduction effect on Cd BAC (76 %) and RBA in both brown and polished rice. Based on mouse bioassays, the supplementation of propolis and its extracts significantly (p < 0.05) reduced the Pb-RBA in brown rice, resulting in a decrease in Pb RBA from 25 % in the control group to 16.5-17.6 %. The results showed that the BAC and RBA of Pb in brown rice with dietary supplements decreased significantly, which may be related to the enhanced inhibitory effect of high Fe. It was also found that the Pb RBA was negatively correlated with the Fe content in mice kidneys. This result provided evidence that antioxidants better inhibit the bioavailability of heavy metals, highlighting that propolis and PA may be alternative dietary supplements for intervening in human Pb and Cd exposure.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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