Dopaminergic manipulations affect the modulation and meta-modulation of movement speed: Evidence from two pharmacological interventions.

Autor: Hickman LJ; Centre for Human Brain Health, School of Psychology, University of Birmingham, B15 2TT, United Kingdom; MRC Cognition and Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, CB2 7EF, United Kingdom. Electronic address: Lydia.Hickman@mrc-cbu.cam.ac.uk., Sowden-Carvalho SL; Centre for Human Brain Health, School of Psychology, University of Birmingham, B15 2TT, United Kingdom., Fraser DS; Centre for Human Brain Health, School of Psychology, University of Birmingham, B15 2TT, United Kingdom., Schuster BA; Centre for Human Brain Health, School of Psychology, University of Birmingham, B15 2TT, United Kingdom; Department of Cognition, Emotion, and Methods in Psychology, University of Vienna, Austria., Rybicki AJ; Centre for Human Brain Health, School of Psychology, University of Birmingham, B15 2TT, United Kingdom., Galea JM; Centre for Human Brain Health, School of Psychology, University of Birmingham, B15 2TT, United Kingdom., Cook JL; Centre for Human Brain Health, School of Psychology, University of Birmingham, B15 2TT, United Kingdom.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2024 Oct 02; Vol. 474, pp. 115213. Date of Electronic Publication: 2024 Aug 23.
DOI: 10.1016/j.bbr.2024.115213
Abstrakt: A body of research implicates dopamine in the average speed of simple movements. However, naturalistic movements span a range of different shaped trajectories and rarely proceed at a single constant speed. Instead, speed is reduced when drawing "corners" compared to "straights" (i.e., speed modulation), and the extent of this slowing down is dependent upon the global shape of the movement trajectory (i.e., speed meta-modulation) - for example whether the shape is an ellipse or a rounded square. At present, it is not known how (or whether) dopaminergic function controls continuous changes in speed during movement execution. The current paper reports effects on these kinematic features of movement following two forms of dopamine manipulation: Study One highlights movement differences in individuals with PD both ON and OFF their dopaminergic medication (N = 32); Study Two highlights movement differences in individuals from the general population on haloperidol (a dopamine receptor blocker, or "antagonist") and placebo (N = 43). Evidence is presented implicating dopamine in speed, speed modulation and speed meta-modulation, whereby low dopamine conditions are associated with reductions in these variables. These findings move beyond vigour models implicating dopamine in average movement speed, and towards a conceptualisation that involves the modulation of speed as a function of contextual information.
Competing Interests: Declaration of Competing Interest The authors declare no competing financial interests.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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