Cobalt exposure and pulmonary function reduction in chronic obstructive pulmonary disease patients: the mediating role of club cell secretory protein.

Autor: Tang F; Department of Interventional Pulmonology and Endoscopic Diagnosis and Treatment Center, Anhui Chest Hospital, Hefei, 230022, Anhui, China., Liu HY; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Furong Road no 678, Hefei, 230601, Anhui, China.; Institute of Respiratory Diseases, Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China., He QY; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Furong Road no 678, Hefei, 230601, Anhui, China., Liu Y; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Furong Road no 678, Hefei, 230601, Anhui, China., Lv LP; Department of Interventional Pulmonology and Endoscopic Diagnosis and Treatment Center, Anhui Chest Hospital, Hefei, 230022, Anhui, China. lvliping1759@sina.com., Fei J; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Furong Road no 678, Hefei, 230601, Anhui, China. clfj2004@21cn.com.; Institute of Respiratory Diseases, Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China. clfj2004@21cn.com., Fu L; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Furong Road no 678, Hefei, 230601, Anhui, China. fulin@ahmu.edu.cn.; Institute of Respiratory Diseases, Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China. fulin@ahmu.edu.cn.; Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, 230032, Anhui, China. fulin@ahmu.edu.cn.; Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease, Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital, Bengbu Medical College, Bengbu, 233030, Anhui, China. fulin@ahmu.edu.cn.
Jazyk: angličtina
Zdroj: Respiratory research [Respir Res] 2024 Aug 24; Vol. 25 (1), pp. 324. Date of Electronic Publication: 2024 Aug 24.
DOI: 10.1186/s12931-024-02950-8
Abstrakt: Background: Cobalt (Co) is a metal which is widely used in the industrial production. The previous studies found the toxic effects of environmental Co exposure on multiple organs. However, the correlation of blood Co concentration with lung function was inconsistent in patients with chronic obstructive pulmonary disease (COPD).
Methods: All 771 stable COPD patients were recruited. Peripheral blood and clinical information were collected. The levels of blood Co and serum CC16 were measured.
Results: Cross-sectional study suggested that the level of blood Co was inversely and dose-dependently related to lung function parameters. Each 1 ppm elevation of blood Co was related to 0.598 L decline in FVC, 0.465 L decline in FEV1, 6.540% decline in FEV1/FVC%, and 14.013% decline in FEV1%, respectively. Moreover, higher age, enrolled in winter, current-smoking, higher smoking amount, and inhaled corticosteroids prominently exacerbated the negative correlation between blood Co and lung function. Besides, serum CC16 content was gradually reduced with blood Co elevation in COPD patients. Besides, serum CC16 was positively correlated with lung function, and inversely related to blood Co. Additionally, decreased CC16 substantially mediated 11.45% and 6.37% Co-triggered downregulations in FEV1 and FEV1%, respectively.
Conclusion: Blood Co elevation is closely related to the reductions of pulmonary function and serum CC16. CC16 exerts a significantly mediating role of Co-related to pulmonary function decrease among COPD patients.
(© 2024. The Author(s).)
Databáze: MEDLINE
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