Premature aging effects on COVID-19 pathogenesis: new insights from mouse models.

Autor: Haoyu W; Center for Cell Lineage Atlas, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. wu_haoyu@gibh.ac.cn., Meiqin L; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China.; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Laboratory Clinical Base, Guangzhou Medical University, Guangzhou, China., Jiaoyang S; Division of Basic Research, Guangzhou National Laboratory, Guangzhou, 510005, China., Guangliang H; Division of Basic Research, Guangzhou National Laboratory, Guangzhou, 510005, China., Haofeng L; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China., Pan C; Center for Cell Lineage Atlas, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China., Xiongzhi Q; Center for Cell Lineage Atlas, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China., Kaixin W; Center for Cell Lineage and Atlas (CCLA), Bioland Laboratory, Guangzhou, China., Mingli H; Center for Cell Lineage Atlas, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China., Xuejie Y; Center for Cell Lineage Atlas, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China., Lämmermann I; Rockfish Bio AG, Vienna, Austria., Grillari J; Austrian Cluster for Tissue Regeneration, Vienna, Austria.; Institute of Molecular Biotechnology, BOKU University, Vienna, Austria.; Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, 1200, Vienna, Austria., Zhengli S; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China., Jiekai C; Center for Cell Lineage Atlas, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. chen_jiekai@gibh.ac.cn.; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation, Chinese Academy of Sciences, Kowloon, 999077, Hong Kong SAR, China. chen_jiekai@gibh.ac.cn., Guangming W; Division of Basic Research, Guangzhou National Laboratory, Guangzhou, 510005, China. wu_guangming@gzlab.ac.cn.; The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. wu_guangming@gzlab.ac.cn.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Aug 24; Vol. 14 (1), pp. 19703. Date of Electronic Publication: 2024 Aug 24.
DOI: 10.1038/s41598-024-70612-2
Abstrakt: Aging is identified as a significant risk factor for severe coronavirus disease-2019 (COVID-19), often resulting in profound lung damage and mortality. Yet, the biological relationship between aging, aging-related comorbidities, and COVID-19 remains incompletely understood. This study aimed to elucidate the age-related COVID19 pathogenesis using an Hutchinson-Gilford progeria syndrome (HGPS) mouse model, a premature aging disease model, with humanized ACE2 receptors. Pathological features were compared between young, aged, and HGPS hACE2 mice following SARS-CoV-2 challenge. We demonstrated that young mice display robust interferon response and antiviral activity, whereas this response is attenuated in aged mice. Viral infection in aged mice results in severe respiratory tract hemorrhage, likely contributing a higher mortality rate. In contrast, HGPS hACE2 mice exhibit milder disease manifestations characterized by minor immune cell infiltration and dysregulation of multiple metabolic processes. Comprehensive transcriptome analysis revealed both shared and unique gene expression dynamics among different mouse groups. Collectively, our studies evaluated the impact of SARS-CoV-2 infection on progeroid syndromes using a HGPS hACE2 mouse model, which holds promise as a useful tool for investigating COVID-19 pathogenesis in individuals with premature aging.
(© 2024. The Author(s).)
Databáze: MEDLINE
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