Spatial heterogeneity and prognostic significance of TAMs and TILs infiltrates in different staging esophageal squamous carcinoma.

Autor:	Li Y; Department of Pathology, Shihezi University School of Medicine / Department of Pathology, The First Affiliated Hospital, Shihezi University, Xinjiang 832002, China; Medical Research Center & Department of Pathology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China., Liu J; Department of Pathology, Shihezi University School of Medicine / Department of Pathology, The First Affiliated Hospital, Shihezi University, Xinjiang 832002, China., Qi L; Department of Medical Oncology, First Affiliated Hospital, Shihezi University School of Medicine, Xinjiang 832002, China., Yuan X; Department of Pathology, Shihezi University School of Medicine / Department of Pathology, The First Affiliated Hospital, Shihezi University, Xinjiang 832002, China., Yang K; Department of Pathology, Shihezi University School of Medicine / Department of Pathology, The First Affiliated Hospital, Shihezi University, Xinjiang 832002, China., Ren Y; Department of Pathology, Shihezi University School of Medicine / Department of Pathology, The First Affiliated Hospital, Shihezi University, Xinjiang 832002, China., Shi Q; Medical Research Center & Department of Pathology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China., Xu G; Medical Research Center & Department of Pathology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China., Wang W; Department of Pathology, Shihezi University School of Medicine / Department of Pathology, The First Affiliated Hospital, Shihezi University, Xinjiang 832002, China., Luo C; Department of Pathology, Shihezi University School of Medicine / Department of Pathology, The First Affiliated Hospital, Shihezi University, Xinjiang 832002, China., Wang L; Department of Pathology, Shihezi University School of Medicine / Department of Pathology, The First Affiliated Hospital, Shihezi University, Xinjiang 832002, China., Liang W; Department of Pathology, Shihezi University School of Medicine / Department of Pathology, The First Affiliated Hospital, Shihezi University, Xinjiang 832002, China., He Z; Department of Pathology, Shihezi University School of Medicine / Department of Pathology, The First Affiliated Hospital, Shihezi University, Xinjiang 832002, China., Zhou W; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China., Fei J; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, China., Chen W; Department of Gastroenterology, First Affiliated Hospital, Shihezi University School of Medicine, Xinjiang 832002, China., Gu W; Australian Institute of Bioengineering and Nanotechnology, University of Queensland, QLD, 4072, Australia., Li F; Department of Pathology, Shihezi University School of Medicine / Department of Pathology, The First Affiliated Hospital, Shihezi University, Xinjiang 832002, China; Medical Research Center & Department of Pathology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China. Electronic address: lifeng7855@126.com., Hu J; Department of Pathology, Shihezi University School of Medicine / Department of Pathology, The First Affiliated Hospital, Shihezi University, Xinjiang 832002, China. Electronic address: jianming.120@163.com.
Jazyk:	angličtina
Zdroj:	Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2025 Jan; Vol. 57 (1), pp. 149-159. Date of Electronic Publication: 2024 Aug 24.
DOI:	10.1016/j.dld.2024.08.003
Abstrakt:	Background: The prognostic value and clinical relevance of tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) in esophageal squamous cell carcinoma (ESCC) remain unclear. Aims: To investigate the prognostic value and functional involvement of TILs in ESCC. Methods: We included 40 patients across different stages of ESCC from Xinjiang. Multiplex fluorescent immunohistochemistry characterized TILs and TAMs. TILs in different tumor regions were quantified and correlated with overall survival (OS) using log-rank test and Cox regression analyses. Results: Invasive ESCC exhibited increased CD4 T cells and Tregs compared to carcinoma in situ, with a higher Tregs/CD4 T cells ratio (p < 0.05). TAMs, primarily in stromal regions, were significantly associated with Foxp3+ cells (p < 0.05). Higher infiltration of stromal TAMs and a higher CD4/CD8 T cells ratio correlated with poorer OS, while a higher CD8 T/Foxp3+ cells ratio indicated better survival. Multivariate Cox analysis revealed TNM stage, tumor length, and stromal CD4/CD8 T cells ratio as independent prognostic factors (p < 0.05). An immune prognostic risk score-based nomogram was constructed to predict patient outcomes. Conclusions: The spatial distribution and abundance of TILs significantly correlated with prognosis, providing a useful immune classification for ESCC. Competing Interests: Conflicts of interest The authors declare that there are no conflict of interests, we do not have any possible conflicts of interest. (Copyright © 2024. Published by Elsevier Ltd.)
Databáze:	MEDLINE
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