Nurture growth: Ketogenic diet therapy and growth velocity in infants under 12 months with epilepsy - A systematic review and infant data study.

Autor: Maass A; Children's Hospital AUF DER BULT, Hannover, Germany., Sutter F; Department of Pediatrics and Adolescent Health, Member of the ERN EpiCARE, Medical University Vienna, Austria., Trimmel-Schwahofer P; Department of Pediatrics and Adolescent Health, Member of the ERN EpiCARE, Medical University Vienna, Austria., Lämmer C; Department of Pediatrics, KFJ Klinik Josefinum Augsburg, Germany., Schoene-Bake JC; Department of Pediatrics, University Hospitals Schleswig-Holstein and University of Luebeck, Germany., Schönlaub A; Department of Pediatrics, Medical University Innsbruck, Austria., Höller A; Department of Pediatrics, Medical University Innsbruck, Austria., Dressler A; Department of Pediatrics and Adolescent Health, Member of the ERN EpiCARE, Medical University Vienna, Austria. Electronic address: anastasia.dressler@meduniwien.ac.at.
Jazyk: angličtina
Zdroj: Epilepsy & behavior : E&B [Epilepsy Behav] 2024 Oct; Vol. 159, pp. 110011. Date of Electronic Publication: 2024 Aug 24.
DOI: 10.1016/j.yebeh.2024.110011
Abstrakt: Ketogenic diet therapy (KDT) is well established for the treatment of early epileptic encephalopathies and specific aetiologies; however, the impact on growth in infancy remains controversial. Our aim was to examine the influence of early KDT on growth velocity and height percentiles completing two tasks. First, we systematically reviewed the literature on growth in infants younger than 12 months. Second, we analysed data from our prospective database, including infants <12 months (n = 63) treated with KDT. The literature review (n = 7) remains descriptive and includes growth percentiles and z-scores as growth velocity was not described. Studies up to 2010 used fasting, calorie restrictions, and ratios >3:1. In individual cases, significant growth delays were found; other authors did not find any changes in growth parameters. Study endpoints in our own cohort included z-scores of growth velocity, standard deviation (SD) of height, weight, BMI, deviation from individual height percentile, and daily macronutrient intake. The median z-score of growth velocity was 1.03 (first year of life). After three months, median daily intake of protein and energy was 1.68 g/kg and 85 kcal/kg. Until the age of one year, neither growth velocity nor individual growth percentiles decreased. Infants showed distinct growth improvements at three months, likely due to continuous nutritional monitoring and reduction in seizures. In the second year of life, z-scores of growth velocity decreased in patients still receiving KDT (from 1.03 at 12 months to -1.5 at 24 months). Furthermore, younger age at epilepsy onset and at KDT start correlated with slower growth velocities in the first year of life. With appropriate nutritional intake and monitoring, KDT does not reduce growth in the first year of life. Future directions might be to study the impact of KDT on growth velocity and growth hormones throughout childhood.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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