Delayed peak antibody titers after the second dose of SARS-CoV-2 vaccine in solid organ transplant recipients: Prospective cohort study.

Autor: Unagami K; Department of Organ Transplant Medicine, Graduate School of Medicine, Tokyo Women's Medical University, Japan; Department of Nephrology, Graduate School of Medicine, Tokyo Women's Medical University, Japan; Department of Urology, Yochomachi Clinic, Tokyo, Japan., Yoshikawa M; Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan., Egawa H; Department of Surgery, Graduate School of Medicine, Tokyo Women's Medical University, Japan. Electronic address: egawa@kuhp.kyoto-u.ac.jp., Ohfuji S; Department of Public Health, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Natori Y; Division of Infectious Disease, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States., Oki R; Department of Organ Transplant Medicine, Graduate School of Medicine, Tokyo Women's Medical University, Japan; Department of Nephrology, Graduate School of Medicine, Tokyo Women's Medical University, Japan., Mori T; Department of Diabetology and Metabolism, Graduate School of Medicine, Tokyo Women's Medical University, Japan., Hattori H; Department of Cardiology, Graduate School of Medicine, Tokyo Women's Medical University, Japan., Ishiwatari A; Department of Urology, Yochomachi Clinic, Tokyo, Japan., Kanzawa T; Department of Urology, Graduate School of Medicine, Tokyo Women's Medical University, Japan; Department of Urology, Yochomachi Clinic, Tokyo, Japan., Shimizu T; Department of Organ Transplant Medicine, Graduate School of Medicine, Tokyo Women's Medical University, Japan; Department of Urology, Graduate School of Medicine, Tokyo Women's Medical University, Japan; Department of Urology, Yochomachi Clinic, Tokyo, Japan., Omoto K; Department of Urology, Graduate School of Medicine, Tokyo Women's Medical University, Japan; Department of Urology, Yochomachi Clinic, Tokyo, Japan., Inui M; Department of Urology, Graduate School of Medicine, Tokyo Women's Medical University, Japan; Department of Urology, Yochomachi Clinic, Tokyo, Japan., Masano Y; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Ito T; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Nakajima D; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Babazono T; Department of Diabetology and Metabolism, Graduate School of Medicine, Tokyo Women's Medical University, Japan., Takagi T; Department of Urology, Graduate School of Medicine, Tokyo Women's Medical University, Japan., Nunoda S; Department of Therapeutic Strategy for Severe Heart Failure, Graduate School of Medicine, Tokyo Women's Medical University, Japan., Tomimaru Y; Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Japan., Imamura R; Department of Urology, Osaka University, Graduate School of Medicine, Japan., Miyagawa S; Department of Cardiovascular Surgery, Osaka University, Graduate School of Medicine, Japan., Toda K; Department of Cardiovascular Surgery, Osaka University, Graduate School of Medicine, Japan., Hatano E; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Date H; Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kyakuno M; Department of Renal Transplantation, Takatsuki General Hospital, Osaka Metropolitan University, Osaka, Japan., Takahara S; Department of Renal Transplantation, Kansai Medical Clinic, Osaka Metropolitan University, Osaka, Japan., Yuzawa K; Department of Transplantation Surgery, National Hospital Organization Mito Medical Center, Ibaraki, Japan., Tanimine N; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Ohdan H; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan., Ishida H; Department of Organ Transplant Medicine, Graduate School of Medicine, Tokyo Women's Medical University, Japan., Hirota Y; Clinical Epidemiology Research Center, Medical Co. LTA (SOUSEIKAI), Fukuoka, Japan.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2024 Oct 03; Vol. 42 (23), pp. 126221. Date of Electronic Publication: 2024 Aug 24.
DOI: 10.1016/j.vaccine.2024.126221
Abstrakt: Poor post-vaccination production of antibody against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a concern among solid organ transplant (SOT) recipients. Furthermore, the timing and kinetics of antibody titers after the second vaccine dose are unknown. We conducted a multicenter prospective observational study that included 614 SOT recipients: 460 kidney, 53 heart, 50 liver, 20 lung, and 31 simultaneous pancreas-kidney (SPK). The participants received two doses of the mRNA vaccine (Pfizer BNT162b2 or Moderna mRNA-1273), as indicated. Serum samples were collected before the first and second vaccinations and at 1, 3, and 6 months after the second vaccine dose, which were then assessed for SARS-CoV-2 antibodies. The overall seropositivity rate was 43% at 1 month after administration of the second vaccine dose; it gradually increased to 68% at 3 months after second dose administration and to 70% at 6 months. In addition, recipient of kidney, lung or SPK transplants had lower antibody titers at the 3- and 6-month time points than did the other recipients. SOT recipients acquired SARS-CoV-2 S-IgG antibodies slowly, and the peak titer differed significantly from that of the general population.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yoshio Hirota reports financial support was provided by Health Labor Administration. Yoshio Hirota reports a relationship with Japan Health Labor Administration that includes: funding grants. The authors of this manuscript have no conflicts of interest to disclose as described by the Vaccine. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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