Causal associations of osteoporosis with stroke: a bidirectional Mendelian randomization study.

Autor: Fan Z; The Department of Orthopedics, Tianjin Hospital, Tianjin, 300070, China., Zhao J; The Department of Orthopedics, Tianjin Hospital, Tianjin, 300070, China., Chen J; The Department of Orthopedics, Tianjin Hospital, Tianjin, 300070, China., Hu W; Department of Spine Surgery, Tianjin Union Medical Center, Tianjin, 300122, China., Ma J; The Department of Orthopedics, Tianjin Hospital, Tianjin, 300070, China.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin Hospital, 122 Munan Road, Tianjin, 300050, China., Ma X; The Department of Orthopedics, Tianjin Hospital, Tianjin, 300070, China. maxinlong23@outlook.com.; Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering, Tianjin Hospital, 122 Munan Road, Tianjin, 300050, China. maxinlong23@outlook.com.
Jazyk: angličtina
Zdroj: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2024 Dec; Vol. 35 (12), pp. 2127-2135. Date of Electronic Publication: 2024 Aug 24.
DOI: 10.1007/s00198-024-07235-w
Abstrakt: This study employed bidirectional Mendelian randomization (MR) to investigate the causal relationship between osteoporosis (OP) and stroke. Utilizing large-scale genome-wide association data revealed a reciprocal relationship: stroke increases the risk of OP, and vice versa. These findings underscore the importance of addressing both conditions for comprehensive patient care.
Introduction: The correlation between OP and stroke is unclear. This study used a two-sample bidirectional MR study to determine the causal relationship between OP and stroke.
Methods: Summary data from genome-wide association studies (GWAS) were used to perform MR analyses. Summary data for OP (n = 300,147), OP with pathological fracture (n = 239,702), and postmenopausal OP with pathological fracture (n = 182,601) were extracted from large-scale GWAS and meta-analyses of European populations in the FinnGen consortium. Similarly, summary data for stroke (n = 446,696), ischemic stroke (IS, n = 440,328), small vessel stroke (SVS, n = 198,048), large artery atherosclerosis stroke (LAS, n = 150,765), and cardioembolic stroke (CES, n = 211,763) were extracted from the MEGASTROKE consortium. Methods such as inverse variance weighted, MR-Egger, and weighted median were applied to perform various outcome analyses for MR.
Results: The results demonstrated significant positive causality of stroke, IS, and LAS on OP (stroke: odds ratio [OR]: 1.39, 95% confidence interval [CI]: 1.04-1.85, and P = 0.027; IS, OR: 2.02, 95% CI: 1.05-3.87, and P = 0.035; LAS: OR: 1.29, 95% CI: 1.08-1.55, and P = 0.005), positive causality of LAS on OP with pathological fracture (LAS: OR: 1.69, 95% CI: 1.18-2.42, and P = 0.004), and positive causality of stroke and LAS on postmenopausal OP with pathological fracture (stroke: OR: 2.02, 95% CI: 1.05-3.87, and P = 0.035; LAS, OR: 1.75, 95% CI: 1.06-2.90, and P = 0.030). There was also a significant positive causal relationship between OP and SVS (OP, OR: 1.08, 95% CI: 1.01-1.14, and P = 0.021).
Conclusion: In conclusion, there is a causal relationship between stroke and OP, suggesting that they may be potential risk factors for each other. Therefore, patients with stroke should receive timely prevention for OP, OP with pathological fracture, and postmenopausal OP with pathological fracture. Similarly, patients with OP may need to be evaluated for potential cardiovascular risks.
Competing Interests: Declarations. Conflicts of interest: None.
(© 2024. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.)
Databáze: MEDLINE