Onset of Spontaneous Filling and Voiding Cycles in the Lower Urinary Tract: A Modeling Study.

Autor: Nunez R; Department Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO, USA.; Department of Mathematics, University of Missouri, Columbia, MO, USA., Alhajjar E; Division of Engineering and Applied Sciences, RAND, Arlington, VA, USA., Jaskowak D; Department of Biomedical Engineering, Florida International University, Miami, FL, USA., Danziger ZC; Department of Rehabilitation Medicine, Division of Physical Therapy, Emory University, Atlanta, GA, USA.; W.H. Coulter Department of Biomedical Engineering, Emory University, Atlanta, GA, USA., Guidoboni G; Maine College of Engineering and Computing, University of Maine, Orono, ME, USA. giovanna.guidoboni@maine.edu.
Jazyk: angličtina
Zdroj: Bulletin of mathematical biology [Bull Math Biol] 2024 Aug 24; Vol. 86 (10), pp. 122. Date of Electronic Publication: 2024 Aug 24.
DOI: 10.1007/s11538-024-01320-1
Abstrakt: Spontaneous filling and voiding cycles represent a key dynamical feature of the healthy lower urinary tract. Some urinary tract dysfunctions, such as over-flow incontinence, may alter the natural occurrence of these cycles. As the function of the lower urinary tract arises from the interplay of a multitude of factors, it is difficult to determine which of them can be modulated to regain spontaneous cycles. In this study, we develop a mathematical model of the lower urinary tract that can capture filling and voiding cycles in the form of periodic solutions of a system of ordinary differential equations. After experimental validation, we utilize this model to study the effect that several physiological quantities have on the onset of cycles. We find that some parameters have an associated numerical threshold that determines whether the system exhibits healthy cycles or settles in a state of constant overflow.
(© 2024. The Author(s), under exclusive licence to the Society for Mathematical Biology.)
Databáze: MEDLINE
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