Clinical efficacy of 595 nm pulsed dye laser in combination with supramolecular salicylic acid in the treatment of rosacea.

Autor: Lei W; Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, 430000, Hubei, China.; Department of Dermatology, No.1 Hospital of China Medical University, 155 North Nanjing Street, Shenyang, 110001, Liaoning, China., Chen H; Department of Cosmetic Dermatology, Shenzhen Coastal Medical Beauty Clinic, Shenzhen, 518064, Guangdong, China., Chen L; Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, 430000, Hubei, China., Li M; Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, 430000, Hubei, China., Zhang J; Department of Dermatology, No. 1 Hospital of Wuhan, Wuhan, 430000, Hubei, China., Xu X; Department of Dermatology, No.1 Hospital of China Medical University, 155 North Nanjing Street, Shenyang, 110001, Liaoning, China. Xuxuegang2606@163.com.
Jazyk: angličtina
Zdroj: Archives of dermatological research [Arch Dermatol Res] 2024 Aug 24; Vol. 316 (8), pp. 579. Date of Electronic Publication: 2024 Aug 24.
DOI: 10.1007/s00403-024-03290-9
Abstrakt: Objective: This research was aimed at ascertaining the clinical effects of 595 nm pulsed dye laser (PDL) in combination with supramolecular salicylic acid (SSA) in the treatment of rosacea.
Methods: Eighty-four patients with rosacea were selected, of which 42 patients treated with PDL alone were considered as the control group, and 42 patients treated with 595 nm PDL in combination with 30% SSA were regarded as the observation group. The treatment continued for 4 months in the two groups. Clinical symptom scores, skin barrier function indicators, serum inflammatory factors, Acne⁃QOL scores and adverse reactions between the two groups were compared.
Results: After treatment, levels of inflammatory factors, clinical symptom scores, transdermal water loss, and oil volume were decreased, and epidermal water content and Acne-QOL scores were increased in both groups (all P < 0.05), and the changes in the observation group were more pronounced versus the control group (all P < 0.05). The difference in the incidence of adverse reactions was not statistically significant between the two groups (P > 0.05).
Conclusion: 595 nm PDL in combination with SSA is safe in the treatment of rosacea.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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