Quality-of-Life Outcomes Following Endoscopic Resection of Sinonasal Inverted Papilloma.

Autor:	Abiri A; Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, U.S.A., Hong EM; Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, U.S.A., Dilley KK; Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, U.S.A., Nguyen TV; Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, U.S.A., Salmon MK; Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A., Grose EM; Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada., Tripathi SH; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A., Venkatesh S; Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A., Kim Y; Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A., Lee DJ; Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A., Douglas JE; Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A., Eide JG; Department of Otolaryngology-Head and Neck Surgery, Henry Ford Health System, Detroit, Michigan, U.S.A., Kshirsagar RS; Department of Head and Neck Surgery, Kaiser Permanente Redwood City Medical Center, Redwood City, California, U.S.A., Phillips KM; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A., Sedaghat AR; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, U.S.A., Lee JM; Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada., Tong CCL; Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A., Adappa ND; Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A., Palmer JN; Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A., Kuan EC; Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, U.S.A.; Department of Neurological Surgery, University of California, Irvine, California, U.S.A.
Jazyk:	angličtina
Zdroj:	The Laryngoscope [Laryngoscope] 2024 Aug 24. Date of Electronic Publication: 2024 Aug 24.
DOI:	10.1002/lary.31725
Abstrakt:	Objectives: There is growing interest in assessing patient quality of life (QOL) following treatment of sinonasal tumors, including inverted papilloma (IP). We aimed to elucidate the natural history of postoperative QOL outcomes in IP patients treated with surgery. Methods: Cases of sinonasal IP treated surgically at 4 tertiary academic rhinology centers were retrospectively reviewed. SNOT-22 scores were used to evaluate QOL preoperatively and postoperatively (1, 3, 6, 12 months). Repeated-measures ANOVA assessed for differences in mean scores over time. Linear regression identified factors associated with QOL longitudinally. Results: 373 patients were analyzed. Mean preoperative SNOT-22 score was 20.6 ± 20.4, which decreased to 16.3 ± 18.8 (p = 0.041) and 11.8 ± 15.0 (p < 0.001) at 1 and 3 months postoperatively, respectively. No further changes in SNOT-22 scores occurred beyond 3 months postoperatively (p > 0.05). When analyzed by SNOT-22 subdomains, nasal, sleep, and otologic/facial subdomain scores (all p < 0.05) demonstrated improvement at 12-month follow-up compared with preoperative scores; this was not observed for the emotional subdomain score (p = 0.800). Recurrent cases were associated with higher long-term SNOT-22 scores (β = 7.08; p = 0.017). Age, sex, degree of dysplasia, prior surgery, primary site, and smoking history did not correlate with symptoms (all p > 0.05). Conclusions: QOL outcomes related to IP resection are largely driven by nasal, sleep, and otologic/facial subdomains, though patients appear to experience enduring improvement as early as 3 months postoperatively. Recurrent disease is a major driver of negative QOL. Level of Evidence: 4 Laryngoscope, 2024. (© 2024 The Author(s). The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.)
Databáze:	MEDLINE
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