Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders.

Autor: Antonijevic M; Université de Caen Normandie, Normandie Univ., CERMN, Caen, France., Dallemagne P; Université de Caen Normandie, Normandie Univ., CERMN, Caen, France., Rochais C; Université de Caen Normandie, Normandie Univ., CERMN, Caen, France.
Jazyk: angličtina
Zdroj: Medicinal research reviews [Med Res Rev] 2025 Jan; Vol. 45 (1), pp. 274-310. Date of Electronic Publication: 2024 Aug 24.
DOI: 10.1002/med.22075
Abstrakt: Neuronal survival depends on neurotrophins and their receptors. There are two types of neurotrophin receptors: a nonenzymatic, trans-membrane protein of the tumor necrosis factor receptor (TNFR) family-p75 receptor and the tyrosine kinase receptors (TrkR) A, B, and C. Activation of the TrkBR by brain-derived neurotrophic factor (BDNF) or neurotrophin 4/5 (NT-4/5) promotes neuronal survival, differentiation, and synaptic function. It is shown that in the pathogenesis of several neurodegenerative conditions (Alzheimer's disease, Parkinson's disease, Huntington's disease) the BDNF/TrkBR signaling pathway is impaired. Since it is known that GPCRs and TrkR are regulating several cell functions by interacting with each other and generating a cross-communication in this review we have focused on the interaction between different GPCRs and their ligands on BDNF/TrkBR signaling pathway.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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