Machine learning models for outcome prediction in thrombectomy for large anterior vessel occlusion.

Autor: Shirvani O; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases, Bonn, Germany., Warnat-Herresthal S; German Center for Neurodegenerative Diseases, Bonn, Germany.; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Savchuk I; German Center for Neurodegenerative Diseases, Bonn, Germany., Bode FJ; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany., Nitsch L; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany., Stösser S; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany., Ebrahimi T; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany., von Danwitz N; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany., Asperger H; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany., Layer J; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany., Meissner J; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany., Thielscher C; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany., Dorn F; Department of Diagnostic and Interventional Neuroradiology, University Hospital Bonn, Bonn, Germany., Lehnen N; Department of Diagnostic and Interventional Neuroradiology, University Hospital Bonn, Bonn, Germany., Schultze JL; German Center for Neurodegenerative Diseases, Bonn, Germany.; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany., Petzold GC; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases, Bonn, Germany., Weller JM; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany.; Department of Neurooncology, University Hospital Bonn, Bonn, Germany.
Jazyk: angličtina
Zdroj: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2024 Oct; Vol. 11 (10), pp. 2696-2706. Date of Electronic Publication: 2024 Aug 23.
DOI: 10.1002/acn3.52185
Abstrakt: Objective: Predicting long-term functional outcomes shortly after a stroke is challenging, even for experienced neurologists. Therefore, we aimed to evaluate multiple machine learning models and the importance of clinical/radiological parameters to develop a model that balances minimal input data with reliable predictions of long-term functional independency.
Methods: Our study utilized data from the German Stroke Registry on patients with large anterior vessel occlusion who underwent endovascular treatment. We trained seven machine learning models using 30 parameters from the first day postadmission to predict a modified Ranking Scale of 0-2 at 90 days poststroke. Model performance was assessed using a 20-fold cross-validation and one-sided Wilcoxon rank-sum tests. Key features were identified through backward feature selection.
Results: We included 7485 individuals with a median age of 75 years and a median NIHSS score at admission of 14 in our analysis. Our Deep Neural Network model demonstrated the best performance among all models including data from 24 h postadmission. Backward feature selection identified the seven most important features to be NIHSS after 24 h, age, modified Ranking Scale after 24 h, premorbid modified Ranking Scale, intracranial hemorrhage within 24 h, intravenous thrombolysis, and NIHSS at admission. Narrowing the Deep Neural Network model's input data to these features preserved the high performance with an AUC of 0.9 (CI: 0.89-0.91).
Interpretation: Our Deep Neural Network model, trained on over 7000 patients, predicts 90-day functional independence using only seven clinical/radiological features from the first day postadmission, demonstrating both high accuracy and practicality for clinical implementation on stroke units.
(© 2024 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
Databáze: MEDLINE
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