Incidence of cardiovascular disease in a cohort of mine workers exposed to ultrafine aluminum powder in Ontario, Canada.

Autor: Zarnke A; School of Kinesiology and Health Sciences, Laurentian University, Sudbury, Ontario, Canada.; The Occupational Health Clinics for Ontario Workers, Sudbury, Ontario, Canada.; The Centre for Research in Occupational Safety and Health (CROSH), Laurentian University, Sudbury, Ontario, Canada., Rhodes S; The Occupational Health Clinics for Ontario Workers, Sudbury, Ontario, Canada., DeBono N; Occupational Cancer Research Centre, Ontario Health, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Berriault C; Occupational Cancer Research Centre, Ontario Health, Toronto, Ontario, Canada., Dorman SC; School of Kinesiology and Health Sciences, Laurentian University, Sudbury, Ontario, Canada.; The Centre for Research in Occupational Safety and Health (CROSH), Laurentian University, Sudbury, Ontario, Canada.
Jazyk: angličtina
Zdroj: American journal of industrial medicine [Am J Ind Med] 2024 Oct; Vol. 67 (10), pp. 933-941. Date of Electronic Publication: 2024 Aug 23.
DOI: 10.1002/ajim.23646
Abstrakt: Background: A retrospective cohort study was conducted to estimate associations between an ultrafine aluminum powder, McIntyre Powder (MP), and cardiovascular disease incidence in a cohort of mine workers from Ontario, Canada. Disease outcomes included ischemic heart disease (IHD), acute myocardial infarction (AMI), congestive heart failure (CHF), and strokes and transient ischemic attacks (STIA).
Methods: Using work history records from the Ontario Mining Master File (MMF) mine workers were followed for disease incidence in administrative health records. The analysis included 25,813 mine workers who were exposed to MP between 1943 and 1979 and followed for cardiovascular disease (CVD) diagnoses between 2006 and 2018. Cardiovascular disease cases were ascertained using physician, hospital, and ambulatory care records. Poisson regression models were used to estimate age and birth-year adjusted incidence rate ratios (RR) and 95% confidence intervals (CI) for associations between MP exposure and CVD outcomes.
Results: Ever-exposure to MP was positively associated with modest increases in the incidence rate of IHD, AMI, and CHF, but not STIA, using both assessment approaches. Duration of self-reported MP exposure was positively associated with monotonically increasing rates of IHD and AMI compared to never-exposed miners, with the greatest association observed among miners with >20 years of exposure (for IHD: RR 1.24, 95% CI: 0.91-1.68; and for AMI: RR 1.52, 95% CI 1.01-2.28).
Conclusion: Mine workers ever-exposed to MP had modestly elevated rates of CVD. The rate of CVD diagnoses appeared to increase with longer duration of exposure when assessed by both self-reported exposure and through historical records.
(© 2024 The Authors. Journal of Cellular Physiology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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