Disrupted brain functional connectivity as early signature in cognitively healthy individuals with pathological CSF amyloid/tau.

Autor: Al-Ezzi A; Department of Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, USA. hakim.alezzi@hmri.org., Arechavala RJ; Department of Environmental and Occupational Health, Center for Occupational and Environmental Health (COEH), University of California, Irvine, CA, USA., Butler R; Department of Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, USA., Nolty A; Fuller Theological Seminary, Pasadena, CA, USA., Kang JJ; The Hill Medical Corporation, Pasadena, CA, USA., Shimojo S; The Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Wu DA; The Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Fonteh AN; Department of Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, USA., Kleinman MT; Department of Environmental and Occupational Health, Center for Occupational and Environmental Health (COEH), University of California, Irvine, CA, USA., Kloner RA; Department of Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, USA.; Department of Cardiovascular Research, Huntington Medical Research Institutes, Pasadena, CA, USA., Arakaki X; Department of Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, USA. xianghong.arakaki@hmri.org.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2024 Aug 23; Vol. 7 (1), pp. 1037. Date of Electronic Publication: 2024 Aug 23.
DOI: 10.1038/s42003-024-06673-w
Abstrakt: Alterations in functional connectivity (FC) have been observed in individuals with Alzheimer's disease (AD) with elevated amyloid (Aβ) and tau. However, it is not yet known whether directed FC is already influenced by Aβ and tau load in cognitively healthy (CH) individuals. A 21-channel electroencephalogram (EEG) was used from 46 CHs classified based on cerebrospinal fluid (CSF) Aβ tau ratio: pathological (CH-PAT) or normal (CH-NAT). Directed FC was estimated with Partial Directed Coherence in frontal, temporal, parietal, central, and occipital regions. We also examined the correlations between directed FC and various functional metrics, including neuropsychology, cognitive reserve, MRI volumetrics, and heart rate variability between both groups. Compared to CH-NATs, the CH-PATs showed decreased FC from the temporal regions, indicating a loss of relative functional importance of the temporal regions. In addition, frontal regions showed enhanced FC in the CH-PATs compared to CH-NATs, suggesting neural compensation for the damage caused by the pathology. Moreover, CH-PATs showed greater FC in the frontal and occipital regions than CH-NATs. Our findings provide a useful and non-invasive method for EEG-based analysis to identify alterations in brain connectivity in CHs with a pathological versus normal CSF Aβ/tau.
(© 2024. The Author(s).)
Databáze: MEDLINE
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