Unraveling the metabolomic profile and acute toxicity of ethanolic extract from Mimosa tenuiflora (Willd.) Poir. root bark.

Autor: de Sousa RP; Natural Products Laboratory (LPN), Postgraduate Program in Chemistry (PPGQ), Federal University of Piaui (UFPI), Teresina, PI, 64.049-550, Brazil., de Oliveira CMF; Addictive Behavior Neuroscience Laboratory (LNCA), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI, 64.049-550, Brazil., de Lima Sousa RC; Addictive Behavior Neuroscience Laboratory (LNCA), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI, 64.049-550, Brazil., Leite LLL; Addictive Behavior Neuroscience Laboratory (LNCA), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI, 64.049-550, Brazil., Oliveira ALO; Addictive Behavior Neuroscience Laboratory (LNCA), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI, 64.049-550, Brazil., Ferreira JVBP; Addictive Behavior Neuroscience Laboratory (LNCA), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI, 64.049-550, Brazil., de Freitas Pessoa AM; Addictive Behavior Neuroscience Laboratory (LNCA), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI, 64.049-550, Brazil., Oliveira JLS; Addictive Behavior Neuroscience Laboratory (LNCA), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI, 64.049-550, Brazil., Meireles VJS; Department of Biology, Federal University of Piauí (UFPI), Picos, PI, 64.607-670, Brazil., Lustosa Barros EM; Laboratory of Functional and Molecular Studies in Physiopharmacology (LAFMOL), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI, 64.049-550, Brazil., Viana Nunes AM; Department of Biophysics and Physiology, Federal University of Piaui (UFPI), Teresina, PI, 64.049-550, Brazil., Chaves MH; Natural Products Laboratory (LPN), Postgraduate Program in Chemistry (PPGQ), Federal University of Piaui (UFPI), Teresina, PI, 64.049-550, Brazil., do Amaral MPM; Addictive Behavior Neuroscience Laboratory (LNCA), Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui (UFPI), Teresina, PI, 64.049-550, Brazil. Electronic address: maur.moura@ufpi.edu.br., Vieira Júnior GM; Natural Products Laboratory (LPN), Postgraduate Program in Chemistry (PPGQ), Federal University of Piaui (UFPI), Teresina, PI, 64.049-550, Brazil. Electronic address: magela@ufpi.edu.br.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 Oct; Vol. 249, pp. 108076. Date of Electronic Publication: 2024 Aug 22.
DOI: 10.1016/j.toxicon.2024.108076
Abstrakt: Mimosa tenuiflora (Fabaceae) is popularly known in Brazil as "Jurema preta". From the bark of its root, "jurema wine" is obtained, a psychedelic drink used in Indigenous religious rituals in Northeastern Brazil. This work aimed to investigate the chemical composition and acute oral toxicity of the ethanolic extract of the root bark from M. tenuiflora (EEMt). EEMt was analyzed by UPLC-QToF-MS/MS and DI-ESI-IT-MS n . Oral administration of EEMt was performed once at doses of 300 and 2000 mg/kg in female Swiss mice. Signs and symptoms of intoxication, as well as mortality were monitored for 14 days. Thirteen compounds were annotated in EEMt: eight type B proanthocyanidins, three alkaloids, a glycosylated flavonol, and a dihydrochalcone derivative. The acute administration of 300 and 2000 mg/kg of EEMt did not show mortality. It also did not change the food intake or body weight of the animals. However, the relative weights of the kidneys were significantly changed for both doses. Changes in hematological and biochemical parameters were found. In addition, histopathological changes were also observed in the heart, liver, and kidneys. Thus, based on our findings, EEMt presented an LD 50 greater than 2000 mg/kg and was therefore classified in category 5 of the Globally Harmonized Classification System (GHS). EEMt showed acute oral toxicity by altering hematological, biochemical and histological parameters.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Gerardo Magela Vieira Junior reports financial support was provided by National Council for Scientific and Technological Development. Mariana Helena Chaves reports financial support was provided by Coordination of Higher Education Personnel Improvement. Mauricio Pires de Moura do Amaral reports financial support was provided by Foundation for Research Support of Piauí State. Gerardo Magela Vieira Junior reports a relationship with National Council for Scientific and Technological Development that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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