Do the biogenic amines ethylamine, ethanolamine and methylamine reach toxic concentrations in foods?

Autor: Sampedro L; Molecular Microbiology Group, Dairy Research Institute (IPLA, CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain; Molecular Microbiology Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain. Electronic address: lorena.sampedro@ipla.csic.es., Casado A; Molecular Microbiology Group, Dairy Research Institute (IPLA, CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain; Molecular Microbiology Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain. Electronic address: angel.casado@ipla.csic.es., Redruello B; Molecular Microbiology Group, Dairy Research Institute (IPLA, CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain; Molecular Microbiology Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain. Electronic address: bredruel@ipla.csic.es., Del Rio B; Molecular Microbiology Group, Dairy Research Institute (IPLA, CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain; Molecular Microbiology Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain. Electronic address: beadelrio@ipla.csic.es., Alvarez MA; Molecular Microbiology Group, Dairy Research Institute (IPLA, CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain; Molecular Microbiology Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain. Electronic address: maag@ipla.csic.es.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Oct; Vol. 192, pp. 114947. Date of Electronic Publication: 2024 Aug 22.
DOI: 10.1016/j.fct.2024.114947
Abstrakt: Ethylamine, ethanolamine and methylamine are biogenic amines (BA) - active metabolites that, despite having important biological functions, may accumulate at toxic concentrations in certain foods. Very little information exists on the toxicity of these BA in this context. This study provides new insights into their cytotoxicity with respect to a human intestinal epithelial cell line, as assessed using real-time cell analyzer technology. A preliminary evaluation of the cytotoxic mode of action was also performed. The present results show that only ethylamine was cytotoxic for these cells at food concentrations. These new data should help establish legal limits for these BA in foods.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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