UV light exposure versus vitamin D supplementation: A comparison of health benefits and vitamin D metabolism in a pig model.

Autor: Kühn J; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany. Electronic address: julia.kuehn@landw.uni-halle.de., Brandsch C; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany., Bailer AC; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), Halle-Jena-Leipzig, Germany., Kiourtzidis M; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), Halle-Jena-Leipzig, Germany., Hirche F; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany., Chen CY; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; DZHK, German Centre for Cardiovascular Research, Berlin, Germany., Markó L; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; DZHK, German Centre for Cardiovascular Research, Berlin, Germany., Bartolomaeus TUP; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; DZHK, German Centre for Cardiovascular Research, Berlin, Germany., Löber U; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; DZHK, German Centre for Cardiovascular Research, Berlin, Germany., Michel S; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany., Wensch-Dorendorf M; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany., Forslund-Startceva SK; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, Germany; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; DZHK, German Centre for Cardiovascular Research, Berlin, Germany; Structural and Computational Biology Unit, EMBL, Heidelberg, Germany., Stangl GI; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), Halle-Jena-Leipzig, Germany.
Jazyk: angličtina
Zdroj: The Journal of nutritional biochemistry [J Nutr Biochem] 2024 Dec; Vol. 134, pp. 109746. Date of Electronic Publication: 2024 Aug 22.
DOI: 10.1016/j.jnutbio.2024.109746
Abstrakt: There is limited data on the effect of UV light exposure versus orally ingested vitamin D 3 on vitamin D metabolism and health. A 4-week study with 16 pigs (as a model for human physiology) was conducted. The pigs were either supplemented with 20 µg/d vitamin D 3 or exposed to UV light for 19 min/d to standardize plasma 25-hydroxyvitamin D 3 levels. Important differences were higher levels of stored vitamin D 3 in skin and subcutaneous fat, higher plasma concentrations of 3-epi-25-hydroxyvitamin D 3 and increases of cutaneous lumisterol 3 in UV-exposed pigs compared to supplemented pigs. UV light exposure compared to vitamin D 3 supplementation resulted in lower hepatic cholesterol, higher circulating plasma nitrite, a marker of the blood pressure-lowering nitric oxide, and a reduction in the release of pro- and anti-inflammatory cytokines from stimulated peripheral blood mononuclear cells. However, plasma metabolome and stool microbiome analyses did not reveal any differences between the two groups. To conclude, the current data show important health relevant differences between oral vitamin D 3 supplementation and UV light exposure. The findings may also partly explain the different vitamin D effects on health parameters obtained from association and intervention studies.
Competing Interests: Declaration of competing interest The authors declare that there are no conflicts of interests.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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