THP as a sensor for the electrochemical detection of H 2 O 2 .

Autor: Failla M; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Turin, Italy., Ferlazzo A; Department of Chemical Sciences and INSTM Research Unit, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy., Abbate V; Institute of Pharmaceutical Sciences, King's College London, London, UK., Neri G; Department of Engineering, University of Messina, Messina 98166, Italy., Saccullo E; Department of Drug and Health Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy; Department of Biomedical and Biotechnological Sciences (Biometec), University of Catania, Via Santa Sofia 97, 95123 Catania, Italy., Gulino A; Department of Chemical Sciences and INSTM Research Unit, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy., Rescifina A; Department of Drug and Health Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy., Patamia V; Department of Drug and Health Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy. Electronic address: vincenzo.patamia@unict.it., Floresta G; Department of Drug and Health Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy. Electronic address: giuseppe.floresta@unict.it.
Jazyk: angličtina
Zdroj: Bioorganic chemistry [Bioorg Chem] 2024 Nov; Vol. 152, pp. 107721. Date of Electronic Publication: 2024 Aug 14.
DOI: 10.1016/j.bioorg.2024.107721
Abstrakt: Hydrogen peroxide (H 2 O 2 ) detection is paramount in biological and clinical domains due to its pivotal role in various physiological and pathological processes. This molecule is a crucial metabolite and effector in cellular redox mechanisms, influencing diverse cellular signaling pathways and bolstering the body's defense mechanisms against infection and oxidative stress. Organic molecule-based electrodes present unique advantages such as operational versatility and scalability, rendering them attractive candidates for sensor development across diverse fields encompassing food safety, healthcare, and environmental monitoring. This study explores the electrochemical properties of a tris(3-hydroxypyridin-4-one) THP, which has been unexplored in electrochemical sensing. Leveraging THP's chelating properties, we aimed to develop an electrochemical probe for hydrogen peroxide detection. Our investigations reveal promising results, with the developed sensor exhibiting a low limit of detection (LOD) of 144 nM, underscoring its potential utility in sensitive and selective H 2 O 2 detection applications. In addition, the new sensor was also tested on fetal bovine serum (FBS) to emphasize future applications on biological matrices. This research signifies a significant stride in advancing electrochemical sensor technologies for hydrogen peroxide detection with several novelties related to the usage of THP, such as high sensitivity and selectivity, performance in biological matrices, repeatability, stability, and reproducibility, economical and practical advantages. This research opens new avenues for enhanced biomedical diagnostics and therapeutic interventions.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: