ENDOTHELIAL-DEPENDENT VASCULAR REACTIVITY AFTER CARDIOPULMONARY BYPASS IS ASSOCIATED WITH UNIQUE METABOLOMIC SIGNATURES.

Autor:	Stark RJ; Division of Pediatric Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Schrimpe-Rutledge AC; Vanderbilt Center for Innovative Technology, Nashville, Tennessee., Codreanu SG; Vanderbilt Center for Innovative Technology, Nashville, Tennessee., Sherrod SD; Vanderbilt Center for Innovative Technology, Nashville, Tennessee., McLean JA; Vanderbilt Center for Innovative Technology, Nashville, Tennessee., Krispinsky LT; Division of Pediatric Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Lamb FS; Division of Pediatric Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Jazyk:	angličtina
Zdroj:	Shock (Augusta, Ga.) [Shock] 2024 Nov 01; Vol. 62 (5), pp. 656-662. Date of Electronic Publication: 2024 Aug 12.
DOI:	10.1097/SHK.0000000000002446
Abstrakt:	Abstract: Cardiopulmonary bypass (CPB), an extracorporeal method necessary for the surgical correction of complex congenital heart defects, incites significant inflammation that affects vascular function. These changes are associated with alterations in cellular metabolism that promote energy production to deal with this stress. Utilizing laser Doppler perfusion monitoring coupled with iontophoresis in patients undergoing corrective heart surgery, we hypothesized that temporal, untargeted metabolomics could be performed to assess the link between metabolism and vascular function. Globally, we found 2,404 unique features in the plasma of patients undergoing CPB. Metabolites related to arginine biosynthesis were the most altered by CPB. Correlation of metabolic profiles with endothelial-dependent (acetylcholine [ACh]) or endothelial-independent (sodium nitroprusside [SNP]) vascular reactivity identified purine metabolism being most consistently associated with either vascular response. Concerning ACh-mediated responses, acetylcarnitine levels were most strongly associated, while glutamine levels were associated with both ACh and SNP responsiveness. These data provide insight into the metabolic landscape of children undergoing CPB for corrective heart surgery and provide detail into how these metabolites relate to physiological aberrations in vascular function. Competing Interests: The authors report no conflicts of interest. (Copyright © 2024 by the Shock Society.)
Databáze:	MEDLINE
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