Clinical characteristics and phenoconversion in isolated REM sleep behavior disorder: a prospective single-center study in Korea, compared with Montreal cohort.

Autor:	Byun JI; Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Republic of Korea., Sunwoo JS; Department of Neurology, Kangbuk Samsung Hospital, Seoul, Republic of Korea., Shin YW; Department of Neurology, Inha University Hospital, Incheon, Republic of Korea., Shin JW; Department of Neurology, CHA University, CHA Bundang Medical Center, Seongnam, Republic of Korea., Kim TJ; Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea., Jun JS; Department of Neurology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea., Shin JH; Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Kim HJ; Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Montplaisir J; Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Québec, Canada., Gagnon JF; Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Québec, Canada.; Department of Psychology, Université du Québec à Montréal, Montreal, Québec, Canada., Pelletier A; Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Québec, Canada.; Research Institute of McGill University Health Centre, Montreal, Québec, Canada., Delva A; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Québec, Canada., Postuma RB; Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montreal, Québec, Canada.; Research Institute of McGill University Health Centre, Montreal, Québec, Canada.; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Québec, Canada., Jung KY; Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jazyk:	angličtina
Zdroj:	Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine [J Clin Sleep Med] 2025 Jan 01; Vol. 21 (1), pp. 81-88.
DOI:	10.5664/jcsm.11318
Abstrakt:	Study Objectives: Isolated rapid eye movement sleep behavior disorder is a prodromal synucleinopathy, but its conversion rate and subtypes can vary among different cohorts. We report the clinical characteristics and phenoconversion rate of the large single-center isolated rapid eye movement sleep behavior disorder cohort in Korea and compared it to the Montreal cohort. Methods: This prospective cohort study examined 238 patients with polysomnography confirmed isolated rapid eye movement sleep behavior disorder from Seoul National University Hospital (SNUH) who completed at least 1 follow-up evaluation. We compared the baseline and phenoconversion data of the SNUH cohort to those of 242 isolated rapid eye movement sleep behavior disorder patients in the Montreal cohort. Results: In the SNUH cohort, age at rapid eye movement sleep behavior disorder diagnosis was similar (66.4 ± 7.8 vs 65.6 ± 8.4, P = .265), but the proportion of men was lower (63.0% vs 74.0%, P = .01), and the duration of follow-up was shorter than that in the Montreal cohort (3.7 ± 2.0 vs 4.8 ± 3.6 years, P < .001). During follow-up, 34 (11.8%) patients in the SNUH cohort converted to neurodegenerative disease: 18 (52.9%) to Parkinson's disease, 9 (26.5%) to dementia with Lewy bodies, and 7 (20.6%) to multiple system atrophy. The conversion rate in the SNUH cohort was 15% after 3 years, 22% after 5 years, and 32% after 7 years, which was significantly lower than that of the Montreal cohort (log-rank test, P = .002). Among phenoconversion subtype, fewer patients in the SNUH group than in the Montreal group converted to dementia with Lewy bodies (Gray's test P = .001). Conclusions: Through a comparative analysis between the SNUH and Montreal cohorts, we identified a significant difference in phenoconversion rates, particularly for dementia with Lewy bodies patients. These findings underscore the importance of further research into the underlying factors, such as racial and geographical factors contributing to such disparities. Citation: Byun J-I, Sunwoo J-S, Shin YW, et al. Clinical characteristics and phenoconversion in isolated REM sleep behavior disorder: a prospective single-center study in Korea, compared with Montreal cohort. J Clin Sleep Med . 2025;21(1):81-88. (© 2025 American Academy of Sleep Medicine.)
Databáze:	MEDLINE
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