Associations Between Brain Metabolites Measured With MR Spectroscopy and Head Impacts in High School American Football Athletes.

Autor: Liu Z; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA., Dudley JA; Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Diekfuss JA; Emory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA., Ahmed N; Department of Neuroscience, Georgia Institute of Technology, Atlanta, Georgia, USA., Edmondson AD; Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Cecil KM; Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Yuan W; Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Zuleger TM; Emory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA., Slutsky-Ganesh AB; Emory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA., Barber Foss KD; Emory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA., Myer GD; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.; Emory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA.; Emory Sports Medicine Center, Atlanta, Georgia, USA.; Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA.; The Micheli Center for Sports Injury Prevention, Waltham, MA, USA.; Youth Physical Development Centre, Cardiff Metropolitan University, Wales, United Kingdom., Fleischer CC; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Jazyk: angličtina
Zdroj: Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2024 Aug 23. Date of Electronic Publication: 2024 Aug 23.
DOI: 10.1002/jmri.29581
Abstrakt: Background: While changes in brain metabolites after injury have been reported, relationships between metabolite changes and head impacts are less characterized.
Purpose: To investigate alterations in neurochemistry in high school athletes as a function of head impacts, concussion, and the use of a jugular vein compression (JVC) collar.
Study Type: Prospective controlled trial.
Subjects: A total of 284 male American football players, divided into JVC collar and noncollar groups; 215 included in final analysis (age = 15.9 ± 1.0 years; 114 in collar group).
Field Strength/sequence: 3 Tesla/T 1 -weighted gradient echo, 1 H point resolved spectroscopy, acquired between August and November 2018.
Assessment: Head impacts were quantified using accelerometers. Concussion was diagnosed by medical professionals for each team. Pre- to postseason differences in total N-acetylaspartate (tNAA), total choline (tCho), myo-inositol (myoI), and glutamate + glutamine (Glx), in primary motor cortex (M1) and anterior cingulate cortex (ACC), relative to total creatine (tCr), were determined.
Statistical Tests: Group-wise comparisons were performed using Wilcoxon signed-rank, Friedman's, and Mann-Whitney U tests. Relationships between ∆metabolite/tCr and mean g-force were analyzed using linear regressions accounting for concussion and JVC collar. Significance was set at P ≤ 0.05.
Results: In participants without concussion, a significant decrease in tCho/tCr (0.233 ± 1.40 × 10 -3 to 0.227 ± 1.47 × 10 -7 ) and increase in Glx/tCr (1.60 ± 8.75 × 10 -3 to 1.63 ± 1.08 × 10 -2 ) in ACC were observed pre- to postseason. The relationship between ∆tCho/tCr in M1 and ACC and mean g-force from >80 g to >140 g differed significantly between participants with and without concussion (M1 β ranged from 3.9 × 10 -3 to 2.1 × 10 -3 ; ACC β ranged from 2.7 × 10 -3 to 2.1 × 10 -3 ). Posthoc analyses revealed increased tCho/tCr in M1 was positively associated with mean g-force >100 g (β = 3.6 × 10 -3 ) and >110 g (β = 2.9 × 10 -3 ) in participants with concussion. Significant associations between ∆ myoI / tCr $$ \Delta \mathrm{myoI}/\mathrm{tCr} $$ in ACC and mean g-force >110 g (β = -1.1 × 10 -3 ) and >120 g (β = -1.1 × 10 -3 ) were observed in the collar group only.
Data Conclusion: Diagnosed concussion and the use of a JVC collar result in distinct neurochemical trends after repeated head impacts.
Level of Evidence: 2 TECHNICAL EFFICACY: Stage 3.
(© 2024 The Author(s). Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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