The Impact of Hypertension on Cognitive Decline and Alzheimer's Disease and Its Management: A Systematic Review.

Autor:	Khan AD; Internal Medicine, Frontier Medical & Dental College, Abbottabad, PAK., Elnagar S; Internal Medicine, NewYork-Presbyterian Queens Hospital, New York City, USA., Eltayeb M; Internal Medicine, Namerah General Hospital, Namerah, SAU., Baluch SK; Internal Medicine, Universidad Autónoma de Guadalajara, Guadalajara, MEX., Kumar A; Internal Medicine, Chandka Medical College, Larkana, PAK., Kumari M; Internal Medicine, Chandka Medical College, Larkana, PAK., Kumari M; Internal Medicine, Chandka Medical College, Larkana, PAK., Fareed MU; Surgery, Nishtar Medical University, Multan, PAK., Rehman A; Surgery, Mayo Hospital, Lahore, PAK., Shehryar A; Internal Medicine, Allama Iqbal Medical College, Lahore, PAK.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jul 23; Vol. 16 (7), pp. e65194. Date of Electronic Publication: 2024 Jul 23 (Print Publication: 2024).
DOI:	10.7759/cureus.65194
Abstrakt:	Hypertension, a major risk factor for cardiovascular diseases, has also been linked to cognitive decline and Alzheimer's disease (AD). This systematic review synthesizes the current evidence on how managing hypertension may influence cognitive health, particularly among elderly populations and those with cognitive impairments. By analyzing data from randomized controlled trials (RCTs), clinical trials, and cross-sectional studies, we evaluated the efficacy of various interventions, including pharmacological treatments, lifestyle modifications, and multidomain approaches that address blood pressure (BP) variability and intensive versus standard blood pressure control. Our findings reveal that effective blood pressure management can mitigate cognitive decline and potentially alter the course of Alzheimer's disease. However, the results also highlight complexities, such as the risk of adverse effects from intensive blood pressure control on cognitive processing and hippocampal volume. This review underscores the need for tailored hypertension management strategies that balance cardiovascular health with cognitive outcomes, suggesting that stabilizing blood pressure variability could play a crucial role. Future research should focus on longitudinal studies to refine these management strategies and enhance treatment guidelines, improving overall outcomes for patients at risk of cognitive decline. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Khan et al.)
Databáze:	MEDLINE
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