Does a large prostate size, small lesion volume, or long needle distance from the probe to the lesion reduce magnetic resonance imaging-targeted cancer detection?

Autor:	Bevill MD; Department of Urology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Drobish JN; Department of Urology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Flynn KJ; Department of Urology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Rajput M; Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Metz C; Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Tracy CR; Department of Urology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Gellhaus PT; Department of Urology, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Jazyk:	angličtina
Zdroj:	Current urology [Curr Urol] 2024 Jun; Vol. 18 (2), pp. 144-147. Date of Electronic Publication: 2024 Jun 21.
DOI:	10.1097/CU9.0000000000000171
Abstrakt:	Background: We aimed to evaluate whether large prostate size, small lesion volume, or long lesion distance from the ultrasound probe tip would decrease cancer detection in transrectal magnetic resonance imaging (MRI)-targeted biopsies. Materials and Methods: Patients who underwent MRI-targeted biopsy at our institution between May 2017 and August 2019 were enrolled in a prospective database. Three to 5 cores were obtained from ≥2 prostate imaging reporting and data system v2 lesions. A multivariable model was created that included needle distance to the lesion, prostate specific antigen, prostate imaging reporting and data system, lesion volume, and prostate volume. Results: A total of 377 patients with 533 lesions underwent a biopsy during the study period. A total of 233 (44%) lesions were positive for prostate cancer, and 173 (32%) lesions had clinically significant prostate cancer. The mean needle distance to the lesion was 11.7 mm (interquartile range, 7.6-15.5 mm). The likelihood of obtaining a positive core on biopsy decreased as the distance from the ultrasound probe increased for all prostate cancers and clinically significant prostate cancer ( p = 0.018 and p = 0.004, respectively). Every 10 mm from the rectum, there was an 8%-10% decrease in the rate of cancer detection. Similarly, as the prostate volume increased, the odds of obtaining a positive core also decreased ( p = 0.039). There was no significant association between the lesion size and amount of cancer obtained on biopsy. Conclusions: Our data showed that transrectal MRI-targeted biopsy cancer detection modestly decreased the lesion from the ultrasound probe and with a large prostate volume but could not prove that lesion volume was a significant predictor of the amount of cancer detected. Competing Interests: The authors declare that they have no conflicts of interest. (Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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