Association of insulin-like growth factor II mrna-binding protein 3 (IMP3) expression with prognostic and morphological factors in endometrial cancer.

Autor:	Salum SOR; Universidade Estadual Paulista Faculdade de Medicina BotucatuSP Brazil Universidade Estadual Paulista, Faculdade de Medicina, Botucatu, SP, Brazil., Candido EB; Universidade Federal de Minas Gerais Belo HorizonteMG Brazil Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Domingues MAC; Universidade Estadual Paulista Faculdade de Medicina BotucatuSP Brazil Universidade Estadual Paulista, Faculdade de Medicina, Botucatu, SP, Brazil., Ojopi EPB; Hospital das Clínicas Faculdade de Medicina BotucatuSP Brazil Hospital das Clínicas, Faculdade de Medicina, Botucatu, SP, Brazil., Tonon ÂFS; Universidade Estadual Paulista Faculdade de Medicina BotucatuSP Brazil Universidade Estadual Paulista, Faculdade de Medicina, Botucatu, SP, Brazil., da Silva-Filho AL; Universidade Estadual Paulista Faculdade de Medicina BotucatuSP Brazil Universidade Estadual Paulista, Faculdade de Medicina, Botucatu, SP, Brazil.; Universidade Federal de Minas Gerais Belo HorizonteMG Brazil Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Jazyk:	angličtina
Zdroj:	Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia [Rev Bras Ginecol Obstet] 2024 Jul 26; Vol. 46. Date of Electronic Publication: 2024 Jul 26 (Print Publication: 2024).
DOI:	10.61622/rbgo/2024rbgo61
Abstrakt:	Objective: Endometrial cancer (EC) is a heterogeneous disease with recurrence rates ranging from 15 to 20%. The discrimination of cases with a worse prognosis aims, in part, to reduce the length of surgical staging in cases with a better prognosis. This study aimed to evaluate the association between Insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression and prognostic and morphological factors in EC. Methods: This retrospective, cross-sectional, analytical study included 79 EC patients - 70 endometrioid carcinoma (EEC) and 9 serous carcinoma (SC) - and 74 benign endometrium controls. IMP3 expression was evaluated by immunohistochemistry-based TMA (Tissue Microarray), and the results were associated with morphological and prognostic factors, including claudins 3 and 4, estrogen and progesterone receptors, TP53, and KI67. Results: IMP3 expression was significantly higher in SC compared to EEC in both extent (p<0.001) and intensity (p=0.044). It was also significantly associated with worse prognostic factors, including degree of differentiation (p=0.024, p<0.001), staging (p<0.001; p<0.001) and metastasis (p=0.002; p<0.001). IMP3 expression was also significant in extent (p=0.002) in endometrial tumors compared with controls. In addition, protein TP53 and KI67 showed significant associations in extent and intensity, respectively. Conclusion: IMP3 expression was associated with worse prognostic factors studied. These findings suggest that IMP3 may be a potential biomarker for EC poorer prognosis. Competing Interests: Conflicts to interest: none to declare.
Databáze:	MEDLINE
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