Excellent Response to 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy in a Patient with Treatment-Related Neuroendocrine Prostate Cancer with Urinary Retention and Rectal Obstruction: A Case Report.

Autor:	Yasukawa R; Department of Urology, Tottori Prefectural Central Hospital, Tottori 680-0901, Japan., Kawamoto B; Department of Urology, Tottori Prefectural Central Hospital, Tottori 680-0901, Japan., Muraoka K; Department of Urology, Tottori Prefectural Central Hospital, Tottori 680-0901, Japan., Nakamura K; Department of Radiology, Tottori Prefectural Central Hospital, Tottori 680-0901, Japan., Honda M; Division of Urology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan., Takenaka A; Division of Urology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan.
Jazyk:	angličtina
Zdroj:	Yonago acta medica [Yonago Acta Med] 2024 Aug 01; Vol. 67 (3), pp. 266-269. Date of Electronic Publication: 2024 Aug 01 (Print Publication: 2024).
DOI:	10.33160/yam.2024.08.010
Abstrakt:	Treatment-related neuroendocrine prostate cancer (tNEPC) occurs after androgen deprivation therapy and has a poor prognosis; however, there are few effective treatments for tNEPC. Therefore, tNEPC management is often challenging. This is a case of a 65-year-old Asian male patient with prostate adenocarcinoma who had metastases at initial presentation. After prostate biopsy revealed neuroendocrine prostate cancer (NEPC), he was treated with platinum-based systemic chemotherapy followed by pembrolizumab treatment. The primary tumor regions temporarily regressed, but progression of the primary tumor resulted in urinary retention and rectal obstruction; therefore, a transverse colostomy was performed, and a urethral catheter was inserted. Following somatostatin receptor scintigraphy (SRS), it was determined that the primary tumor expressed somatostatin receptors. Based on these results, treatment with 177Lu-DODATATE peptide receptor radionuclide therapy was prescribed. Subsequently, the primary tumor regressed remarkably, and the urethral catheter was removed. 177Lu-DOTATATE peptide receptor radionuclide therapy may be an effective option for tNEPC, which has few effective treatment options. Competing Interests: The authors declare no conflicts of interest. (©2024 Tottori University Medical Press.)
Databáze:	MEDLINE
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