Enhancing orthodontic treatment control with fish scale-derived hydroxyapatite nanoparticles: Insights from an animal model study.
| Autor: | Mohammed-Salih HS; Department of Orthodontics, College of Dentistry, University of Baghdad, Baghdad 10047, Iraq., Ghazi A; P.O.P. Department, College of Dentistry, Mustansiriya University, Baghdad 10052, Iraq., Mahmood RI; Department of Biomedical Engineering, College of Engineering, Al-Nahrain University, Jadriya, Baghdad, Iraq., Al-Qazzaz HH; Department of Pathology, Teaching Laboratories, Al Yarmouk Teaching Hospital, Baghdad 10017, Iraq., Supian FL; Department of Physics, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900, Tanjong Malim, Perak, Malaysia., Al-Obaidi JR; Department of Biology, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900, Tanjong Malim, Perak, Malaysia.; Applied Science Research Center. Applied Science Private University, Amman, Jordan., Jabir M; Department of Applied Sciences -University of Technology, Baghdad 10066, Iraq. |
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| Jazyk: | angličtina |
| Zdroj: | The Saudi dental journal [Saudi Dent J] 2024 Aug; Vol. 36 (8), pp. 1128-1134. Date of Electronic Publication: 2024 Jun 04. |
| DOI: | 10.1016/j.sdentj.2024.06.007 |
| Abstrakt: | Objectives: This study investigates the impact of injected fish-scale-derived hydroxyapatite nanoparticles (FsHA-NPs) on orthodontic tooth movement (OTM) and the width of the periodontal ligament (PDL) space. Materials and Methods: Twenty-six Wistar rats underwent mesial orthodontic traction with a force of 50 g for 21 days. Following the application of the orthodontic appliance, the rats were randomly divided into two groups: a control group, which received a 0.3 µg saline injection, and the experimental FsHA group, which received 100 mg/0.3 ml of FsHA-NPs after thorough characterisation. Injections were administered immediately after appliance application and repeated at 7 and 14 days. Statistical analysis was conducted with a significance level of P ≤ 0.05. Result: The experimental group exhibited a significant reduction in OTM at 7-, 14-, and 21-day post-force application. Additionally, a reduction in PDL width was observed in the mesiocervical and disto-apical regions of the mesial and distal roots of the first molar. Conclusion: FsHA-NPs derived from biowaste fish scales exhibit promising potential as biomaterials for enhancing control over OTM. This study underscores the viability, accessibility, and safety of FsHA-NPs as a locally injectable material for orthodontic applications. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 Production and hosting by Elsevier B.V. on behalf of King Saud University.) |
| Databáze: | MEDLINE |
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