Biomarkers of outcome in patients undergoing CD19 CAR-T therapy for large B cell lymphoma.

Autor: Gong IY; Princess Margaret Cancer Center Toronto Ontario Canada.; Division of Medical Oncology and Hematology University Health Network Toronto Ontario Canada., Tran D; Princess Margaret Cancer Center Toronto Ontario Canada.; Division of Medical Oncology and Hematology University Health Network Toronto Ontario Canada., Saibil S; Princess Margaret Cancer Center Toronto Ontario Canada.; Division of Medical Oncology and Hematology University Health Network Toronto Ontario Canada.; Department of Immunology University of Toronto Toronto Ontario Canada., Laister RC; Princess Margaret Cancer Center Toronto Ontario Canada.; Division of Medical Oncology and Hematology University Health Network Toronto Ontario Canada., Kuruvilla J; Princess Margaret Cancer Center Toronto Ontario Canada.; Division of Medical Oncology and Hematology University Health Network Toronto Ontario Canada.
Jazyk: angličtina
Zdroj: HemaSphere [Hemasphere] 2024 Aug 22; Vol. 8 (8), pp. e130. Date of Electronic Publication: 2024 Aug 22 (Print Publication: 2024).
DOI: 10.1002/hem3.130
Abstrakt: CD19-directed autologous chimeric antigen receptor T cell (CAR-T) therapy has transformed the management of relapsed/refractory (R/R) large B cell lymphoma (LBCL). Initially approved in the third line and beyond setting, CAR-T is now standard of care (SOC) for second-line treatment in patients with refractory disease or early relapse (progression within 12 months) following primary chemoimmunotherapy. Despite becoming SOC, most patients do not achieve complete response, and long-term cure is only observed in approximately 40% of patients. Accordingly, there is an urgent need to better understand the mechanisms of treatment failure and to identify patients that are unlikely to benefit from SOC CAR-T. The field needs robust biomarkers to predict treatment outcome, as better understanding of prognostic factors and mechanisms of resistance can inform on the design of novel treatment approaches for patients predicted to respond poorly to SOC CAR-T. This review aims to provide a comprehensive overview of clinical, molecular, imaging, and cellular features that have been shown to influence outcomes of CAR-T therapy in patients with R/R LBCL.
Competing Interests: The authors declare no conflict of interest.
(© 2024 The Author(s). HemaSphere published by John Wiley & Sons Ltd on behalf of European Hematology Association.)
Databáze: MEDLINE
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