Arsenic exposure and measures of glucose tolerance in Bangladeshi adults: A cross-sectional study.

Autor:	Mazumdar M; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Department of Neurology, Boston Children's Hospital, Boston, Massachusetts., Wang X; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Biswas SK; Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut., Biswas PP; Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Farooque A; Department of Neurology, Boston Children's Hospital, Boston, Massachusetts., Lee MS; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., North CM; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts., Afroz S; Dhaka Community Hospital Trust, Dhaka, Bangladesh., Husain N; Dhaka Community Hospital Trust, Dhaka, Bangladesh., Islam F; Dhaka Community Hospital Trust, Dhaka, Bangladesh., Mostofa MG; Dhaka Community Hospital Trust, Dhaka, Bangladesh., Mow S; Dhaka Community Hospital Trust, Dhaka, Bangladesh., Liang L; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Hug C; Consultant, Brookline, Massachusetts., Ludwig DS; New Balance Foundation Obesity Prevention Center, Boston Children's Hospital, Boston, Massachusetts., Quamruzzaman Q; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts., Fleisch AF; Center for Interdisciplinary Population & Health Research, MaineHealth, Westbrook, Maine.; Pediatric Endocrinology and Diabetes, Maine Medical Center, Portland, Maine., Christiani DC; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Jazyk:	angličtina
Zdroj:	Environmental epidemiology (Philadelphia, Pa.) [Environ Epidemiol] 2024 Aug 21; Vol. 8 (5), pp. e330. Date of Electronic Publication: 2024 Aug 21 (Print Publication: 2024).
DOI:	10.1097/EE9.0000000000000330
Abstrakt:	Background: Arsenic has been associated with diabetes and impaired glucose tolerance in many studies, although some reports have shown null findings. Methods: We conducted a cross-sectional study among 300 adults in Bangladesh. Participants were randomly selected from a roster of 1800 people who previously participated in studies of arsenic and skin lesions. We measured fasting glucose and insulin levels. We assessed drinking water arsenic concentration using graphite furnace atomic absorption spectrophotometry (GF-AAS) and toenail arsenic concentration using inductively coupled mass spectrometry (ICP-MS). We ran covariant-adjusted, linear regression and spline models to examine associations of arsenic concentrations with the homeostatic model assessment of insulin resistance (HOMA-IR), a marker of insulin resistance, and HOMA of beta-cell function (HOMA-β), a marker of beta-cell function. Results: Among 285 participants with complete data, the median (IQR) arsenic concentration was 4.0 (6.9) μg/g in toenails and 39.0 (188.5) μg/L in drinking water. Arsenic concentrations were not associated with insulin resistance or beta-cell function. HOMA-IR was 0.67% lower and HOMA-β was 0.28% lower per µg/g increment in toenail arsenic, but these effect estimates were small, and confidence intervals crossed the null value. Conclusions: Although arsenic exposure has been associated with diabetes, we found no evidence of an adverse effect on insulin resistance or beta-cell function. Competing Interests: The authors declare that they have no conflicts of interest with regard to the content of this report. (Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu