The molecular conversations of sarcomas: exosomal non-coding RNAs in tumor's biology and their translational prospects.

Autor: Luongo M; Laboratory of Preclinical and Translational Research, IRCCS CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), 85028, Italy., Laurenziello P; Laboratory of Preclinical and Translational Research, IRCCS CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), 85028, Italy., Cesta G; Laboratory of Preclinical and Translational Research, IRCCS CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), 85028, Italy., Bochicchio AM; Experimental Oncology Unit, IRCCS CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), 85028, Italy., Omer LC; Experimental Oncology Unit, IRCCS CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), 85028, Italy., Falco G; Department of Biology, University of Naples Federico II, Naples, 80126, Italy., Milone MR; AORN San Giuseppe Moscati, Avellino (AV), 83100, Italy., Cibarelli F; AORN San Giuseppe Moscati, Avellino (AV), 83100, Italy., Russi S; Laboratory of Preclinical and Translational Research, IRCCS CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), 85028, Italy. sabino.russi@crob.it., Laurino S; Laboratory of Preclinical and Translational Research, IRCCS CROB Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), 85028, Italy.
Jazyk: angličtina
Zdroj: Molecular cancer [Mol Cancer] 2024 Aug 22; Vol. 23 (1), pp. 172. Date of Electronic Publication: 2024 Aug 22.
DOI: 10.1186/s12943-024-02083-y
Abstrakt: Exosomes mediate cell-to-cell crosstalk involving a variety of biomolecules through an intricate signaling network. In recent years, the pivotal role of exosomes and their non-coding RNAs cargo in the development and progression of several cancer types clearly emerged. In particular, tumor bulk and its microenvironment co-evolve through cellular communications where these nanosized extracellular vesicles are among the most relevant actors. Knowledge about the cellular, and molecular mechanisms involved in these communications will pave the way for novel exosome-based delivery of therapeutic RNAs as well as innovative prognostic/diagnostic tools. Despite the valuable therapeutic potential and clinical relevance of exosomes, their role on sarcoma has been vaguely reported because the rarity and high heterogeneity of this type of cancer. Here, we dissected the scientific literature to unravel the multifaceted role of exosomal non-coding RNAs as mediator of cell-to-cell communications in the sarcoma subtypes.
(© 2024. The Author(s).)
Databáze: MEDLINE
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