Severe COVID-19 in HIV/Leishmania infantum coinfected patient: a successfully managed case report.

Autor: Farias PCS; Departamento de Genética, Universidade Federal de Pernambuco (UFPE), Recife, Brasil. pablo.cantalice@ufpe.br., Bezerra GSN; Department of Nursing & Healthcare, Technological Univeristy of the Shannon: Midlands Midwest, Athlone, N37 HD68, Ireland., Neves PAF; Departamento Medicina Tropical, Universidade Federal de Pernambuco (UFPE), Recife, Brasil.; Departamento de Imunologia, Instituto Aggeu Magalhães, Fundação Oswaldo Cruz, Pernambuco, Brasil., Cabral LP; Departamento de Genética, Universidade Federal de Pernambuco (UFPE), Recife, Brasil., Júnior WLB; Departamento de Parasitologia, Instituto Aggeu Magalhães, Fundação Oswaldo Cruz, Pernambuco, Brasil., Guedes DL; Faculdade de Ciências Médicas, Universidade de Pernambuco, Recife, Brasil.; Núcleo de Ciências da Vida, Centro Acadêmico Do Agreste, Universidade Federal de Pernambuco, Caruaru, Brasil., Xavier AT; Departamento de Parasitologia, Instituto Aggeu Magalhães, Fundação Oswaldo Cruz, Pernambuco, Brasil., Medeiros ZM; Departamento de Parasitologia, Instituto Aggeu Magalhães, Fundação Oswaldo Cruz, Pernambuco, Brasil., Lorena VMB; Departamento de Imunologia, Instituto Aggeu Magalhães, Fundação Oswaldo Cruz, Pernambuco, Brasil., Araújo PSR; Departamento Medicina Tropical, Universidade Federal de Pernambuco (UFPE), Recife, Brasil., de Queiroz Balbino V; Departamento de Genética, Universidade Federal de Pernambuco (UFPE), Recife, Brasil., de Lima Neto RG; Departamento Medicina Tropical, Universidade Federal de Pernambuco (UFPE), Recife, Brasil.
Jazyk: angličtina
Zdroj: BMC infectious diseases [BMC Infect Dis] 2024 Aug 23; Vol. 24 (1), pp. 854. Date of Electronic Publication: 2024 Aug 23.
DOI: 10.1186/s12879-024-09691-5
Abstrakt: Background: Coronavirus disease 2019 originated in China and swiftly spread worldwide, posing a significant threat to public health. Caused by SARS-CoV-2, it manifests as a flu-like illness that can escalate to Acute Respiratory Distress Syndrome, potentially resulting in fatalities. In countries where HIV/Leishmania infantum is endemic, the occurrence of concurrent SARS-CoV-2/HIV/Leishmania infantum infections is a reality, prompting inquiries into appropriate clinical management.
Case Presentation: We present the case of a 48-year-old woman who was hospitalized for 36 days across three different hospitals in the state of Pernambuco, Brazil. She was diagnosed with SARS-CoV-2/HIV/L. infantum coinfection. The patient exhibited severe COVID-19 symptoms, including fever, productive cough, and dyspnea. Throughout her hospitalization, she experienced oxygen saturation levels of ≤ 93%, along with fluctuations in blood pressure, respiratory rate, and heart rate. Her blood tests revealed lymphopenia, leukopenia, and neutropenia, while laboratory results indicated abnormal levels of d-dimer, AST, ALT, lactate dehydrogenase, ferritin, and C-reactive protein. A computed tomography scan revealed 75% involvement of the lung parenchyma with patchy ground-glass opacities.
Conclusion: Against all odds, the patient was discharged. The leukopenia associated with HIV/L. infantum may have played a decisive role. Further studies are necessary to better understand diagnostic strategies and clinical management measures for HIV/L. infantum coinfected patients who are susceptible to SARS-CoV-2 infection.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje