Effectiveness of Exosome Treatment in Androgenetic Alopecia: Outcomes of a Prospective Study.

Autor: Ersan M; Plastic, Reconstructive and Aesthetic Surgery Department, Kozyatagi Hospital, Faculty of Medicine, Yeditepe University, Icerenkoy Mahallesi, Hastahane Sokak, 34752, Atasehir, Istanbul, Turkey. mert.ersan@yeditepe.edu.tr., Ozer E; Plastic, Reconstructive and Aesthetic Surgery Department, Kozyatagi Hospital, Faculty of Medicine, Yeditepe University, Icerenkoy Mahallesi, Hastahane Sokak, 34752, Atasehir, Istanbul, Turkey., Akin O; Dermatology Department, Kozyatagi Hospital, Faculty of Medicine, Yeditepe University, Icerenkoy Mahallesi, Hastahane Sokak, 34752, Atasehir, Istanbul, Turkey., Tasli PN; Genetics and Bioengineering Department, Faculty of Engineering and Architecture, Yeditepe University, Kayisdagi, Inonu Mahallesi, Kayisdagi Caddesi, 34755, Atasehir, Istanbul, Turkey., Sahin F; Genetics and Bioengineering Department, Faculty of Engineering and Architecture, Yeditepe University, Kayisdagi, Inonu Mahallesi, Kayisdagi Caddesi, 34755, Atasehir, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Aesthetic plastic surgery [Aesthetic Plast Surg] 2024 Aug 22. Date of Electronic Publication: 2024 Aug 22.
DOI: 10.1007/s00266-024-04332-3
Abstrakt: Objective: Harnessing the regenerative capabilities of stem cell-derived exosomes holds great promise for developing novel hair growth therapies, offering hope for individuals experiencing hair loss or alopecia. This aimed to elucidate the effect of "foreskin-derived mesenchymal stromal cells derived exosome" injection into the scalp on hair density in patients with androgenetic alopecia and the contribution of this treatment on patient satisfaction.
Method: This prospective study included 30 male patients, aged between 22 and 65, with hair type III-VI according to the Norwood-Hamilton scale. Characterization of the stem cell exosomes was performed with the nanoparticle tracking analysis (NTA), hair densities were calculated via digital imaging analysis, and patient satisfaction was questioned with a modified survey.
Results: NTA results showed a characteristic distribution of peaks for exosomes 139.7 ± 2.3 nm in diameter. A statistically significant increase in hair density was observed in the 4th and 12th weeks after treatment (p < 0.05). Patient-reported satisfaction revealed a statistically significant difference in the answers given in the 12th week compared to the 4th week (p < 0.05). No side effects or complications were observed after exosome injection.
Conclusion: Foreskin-derived mesenchymal stromal cells derived exosome injection increased hair density, with sustained patient satisfaction throughout the study. The exosome application resulted in no side effects.
Level of Evidence Iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
(© 2024. The Author(s).)
Databáze: MEDLINE
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