An old dog with new tricks: TFEB promotes syncytin expression and cell fusion in the human placenta.
| Autor: | Renaud SJ; Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada; Children's Health Research Institute, Lawson Health Research Institute, London, Ontario N6A 5C1, Canada srenaud4@uwo.ca. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Genes & development [Genes Dev] 2024 Sep 19; Vol. 38 (15-16), pp. 695-697. Date of Electronic Publication: 2024 Sep 19. |
| DOI: | 10.1101/gad.352198.124 |
| Abstrakt: | In the human placenta, cell fusion is crucial for forming the syncytiotrophoblast, a multinucleated giant cell essential for maintaining pregnancy and ensuring fetal health. The formation of the syncytiotrophoblast is catalyzed by the evolutionarily modern fusogens syncytin-1 and syncytin-2. In this issue of Genes & Development , Esbin and colleagues (doi:10.1101/gad.351633.124) reveal a critical role for the transcription factor TFEB in the regulation of syncytin expression and the promotion of trophoblast fusion. Notably, TFEB's pro-fusion role operates independently of its well-known functions in lysosome biogenesis and autophagy, suggesting that TFEB has acquired additional functions to promote cell fusion in the human placenta. (© 2024 Renaud; Published by Cold Spring Harbor Laboratory Press.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|