miR-449a mediated repression of the cell cycle machinery prevents neuronal apoptosis.
| Autor: | Chauhan M; Eukaryotic Gene Expression Laboratory, National Institute of Immunology, New Delhi, India. Electronic address: monikachauhan2011@gmail.com., Singh K; Eukaryotic Gene Expression Laboratory, National Institute of Immunology, New Delhi, India., Chongtham C; Molecular Genetics Laboratory, National Institute of Immunology, New Delhi, India., A G A; Molecular Genetics Laboratory, National Institute of Immunology, New Delhi, India., Sharma P; Eukaryotic Gene Expression Laboratory, National Institute of Immunology, New Delhi, India. Electronic address: pushkar@nii.ac.in. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of biological chemistry [J Biol Chem] 2024 Sep; Vol. 300 (9), pp. 107698. Date of Electronic Publication: 2024 Aug 22. |
| DOI: | 10.1016/j.jbc.2024.107698 |
| Abstrakt: | Aberrant activation of the cell cycle of terminally differentiated neurons results in their apoptosis and is known to contribute to neuronal loss in various neurodegenerative disorders like Alzheimer's Disease. However, the mechanisms that regulate cell cycle-related neuronal apoptosis are poorly understood. We identified several miRNA that are dysregulated in neurons from a transgenic APP/PS1 mouse model for AD (TgAD). Several of these miRNA are known to and/or are predicted to target cell cycle-related genes. Detailed investigation on miR-449a revealed the following: a, it promotes neuronal differentiation by suppressing the neuronal cell cycle; b, its expression in cortical neurons was impaired in response to amyloid peptide Aβ Competing Interests: Conflicts of interest The authors declare that there is no conflicts of interest with the contents of this article. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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