Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise.

Autor: Batitucci G; School of Medical Sciences, Obesity and Comorbidities Research Center, University of Campinas - UNICAMP, Campinas, Sao Paulo, Brazil., Abud GF; Department of Health Sciences, Ribeirao Preto Medical School, University of São Paulo - FMRP/USP, Ribeirao Preto, Sao Paulo, Brazil., Ortiz GU; Department of Health Sciences, Ribeirao Preto Medical School, University of São Paulo - FMRP/USP, Ribeirao Preto, Sao Paulo, Brazil., Belisário LF; Laboratory of Exercise Physiology and Metabolism, School of Physical Education and Sports of Ribeirao Preto, University of Sao Paulo - EEFERP/USP, Ribeirao Preto, Brazil., Travieso SG; Department of Health Sciences, Ribeirao Preto Medical School, University of São Paulo - FMRP/USP, Ribeirao Preto, Sao Paulo, Brazil., de Lima Viliod MC; Laboratory of Exercise Physiology and Metabolism, School of Physical Education and Sports of Ribeirao Preto, University of Sao Paulo - EEFERP/USP, Ribeirao Preto, Brazil., Venturini ACR; Laboratory of Exercise Physiology and Metabolism, School of Physical Education and Sports of Ribeirao Preto, University of Sao Paulo - EEFERP/USP, Ribeirao Preto, Brazil., de Freitas EC; Department of Health Sciences, Ribeirao Preto Medical School, University of São Paulo - FMRP/USP, Ribeirao Preto, Sao Paulo, Brazil; Laboratory of Exercise Physiology and Metabolism, School of Physical Education and Sports of Ribeirao Preto, University of Sao Paulo - EEFERP/USP, Ribeirao Preto, Brazil. Electronic address: ellenfreitas@usp.br.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2024 Nov; Vol. 101, pp. 102460. Date of Electronic Publication: 2024 Aug 22.
DOI: 10.1016/j.arr.2024.102460
Abstrakt: Enigmatic sarcopenic obesity is still a challenge for science and adds to the global public health burden. The progressive accumulation of body fat combined with a dysfunctional skeletal muscle structure and composition, oxidative stress, mitochondrial dysfunction, and anabolic resistance, among other aggravating factors, together represent the seriousness and complexity of treating the metabolic disorder of sarcobesity in aging. For this reason, further studies are needed that encourage the support of therapeutic management. It is along these lines that we direct the reader to therapeutic approaches that demonstrate important, but still obscure, outcomes in the physiological conditions of sarcobesity, such as the role of taurine in modulating inflammatory and antioxidant mechanisms in muscle and adipose tissue, as well as the management of gut microbiota, able to systemically re-establish the structure and function of the gut-muscle axis, in addition to the merits of physical exercise as an instrument to improve muscular health and lifestyle quality.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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