Alveolar wall hyperelastic material properties determined using alveolar cluster model with experimental stress-stretch and pressure-volume data.

Autor: Singh D; University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada. Electronic address: d3singh@uwaterloo.ca., Slutsky AS; Unity Health Toronto, Toronto, Ontario, Canada., Cronin DS; University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2024 Nov; Vol. 159, pp. 106685. Date of Electronic Publication: 2024 Aug 10.
DOI: 10.1016/j.jmbbm.2024.106685
Abstrakt: Micro-scale models of lung tissue have been employed by researchers to investigate alveolar mechanics; however, they have been limited by the lack of biofidelic material properties for the alveolar wall. To address this challenge, a finite element model of an alveolar cluster was developed comprising a tetrakaidecahedron array with the nominal characteristics of human alveolar structure. Lung expansion was simulated in the model by prescribing a pressure and monitoring the volume, to produce a pressure-volume (PV) response that could be compared to experimental PV data. The alveolar wall properties in the model were optimized to match experimental PV response of lungs filled with saline, to eliminate surface tension effects and isolate the alveolar wall tissue response. When simulated in uniaxial tension, the model was in agreement with reported experimental properties of uniaxial tension on excised lung tissue. The work presented herein was able to link micro-scale alveolar response to two disparate macroscopic experimental datasets (stress-stretch and PV response of lung) and presents hyperelastic properties of the alveolar wall for use in alveolar scale finite element models and multi-scale models. Future research will incorporate surface tension effects, and investigate alveolar injury mechanisms.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dilaver Singh reports financial support was provided by NSERC. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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