Invasive candidiasis in dogs: A case report and review of the literature.

Autor: Lorenzetti DM; Programa de Pós-Graduação em Medicina Veterinária, Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil. Electronic address: Lorenzetti.dm@gmail.com., Freitas JP; Programa de Pós-Graduação em Medicina Veterinária, Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil., Mazaro RD; Programa de Pós-Graduação em Medicina Veterinária, Universidade Federal de Santa Maria (UFSM), Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil., Beckenkamp MB; Programa de Residência, Clínica de Pequenos Animais, Hospital Veterinário Universitário, Centro de Ciências Rurais (CCR), UFSM, Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil., Weiblen C; Laboratório de Pesquisas Micológicas (LAPEMI), Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde (CCS), UFSM, Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil., de Azevedo MI; Departamento de Medicina Veterinária Preventiva, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Av. Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil., Denardi LB; Laboratório de Pesquisas Micológicas (LAPEMI), Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde (CCS), UFSM, Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil., Santurio JM; Laboratório de Pesquisas Micológicas (LAPEMI), Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde (CCS), UFSM, Av. Roraima 1000, Santa Maria, RS 97105-900, Brazil., Kommers GD; Laboratório de Patologia Veterinária (LPV), Departamento de Patologia, CCS, UFSM, Brazil., Tonin AA; Medicina Veterinária, Instituto Federal de Educação, Ciência e Tecnologia do Amazonas (IFAM), Campus Manaus Zona Leste, Av. Cosme Ferreira 8045, Manaus, AM, 69083-000, Brazil., Fighera RA; Laboratório de Patologia Veterinária (LPV), Departamento de Patologia, CCS, UFSM, Brazil.
Jazyk: angličtina
Zdroj: Journal de mycologie medicale [J Mycol Med] 2024 Sep; Vol. 34 (3), pp. 101502. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1016/j.mycmed.2024.101502
Abstrakt: Invasive candidiasis is characterized by the systemic dissemination of Candida spp. and colonization of multiple organs. We are reporting a case of invasive candidiasis in a 3.5-year-old female mixed-breed dog with a history of limb injury. After clinical evaluation and complementary examinations a sepsis diagnose was established. The patient remained hospitalized under antibiotic therapy, dying three days later. Necropsy revealed white, nodular (pyogranulomas), and multifocal areas on the liver, button ulcers in the stomach and intestines, and a random lung consolidation. Impression smears were made from the liver and lung surface lesions during necropsy showing yeast and pseudohyphae structures. Fragments of these organs were sent for fungal culture and subsequent molecular etiologic characterization, identifying it as Candida albicans. Histological examination of different organs showed pyogranulomatous inflammation surrounding the necrosis areas, which were full of yeast and pseudohyphae, as evidenced by periodic acid Schiff and immunohistochemistry. Neutropenia, as a consequence of sepsis, associated with the use of antibiotics may have allowed yeast invasion and proliferation in the mucosa of the gastrointestinal tract, reaching the liver and lungs through hematogenous route. Invasive candidiasis is a rare canine disease, and no other cases of neutropenia associated with antibiotic therapy, as a predisposing factors, have been reported.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 SFMM. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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