Influence of membrane on the antigen presentation of the HIV-1 envelope membrane proximal external region (MPER).

Autor: López CA; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA., Alam SM; Department of Medicine, Duke University School of Medicine, Durham, NC, 27710, USA; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA., Derdeyn CA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Haynes BF; Department of Medicine, Duke University School of Medicine, Durham, NC, 27710, USA; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA; Department of Immunology, Duke University of School of Medicine, Durham, NC, USA. Electronic address: barton.haynes@duke.edu., Gnanakaran S; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA. Electronic address: gnana@lanl.gov.
Jazyk: angličtina
Zdroj: Current opinion in structural biology [Curr Opin Struct Biol] 2024 Oct; Vol. 88, pp. 102897. Date of Electronic Publication: 2024 Aug 21.
DOI: 10.1016/j.sbi.2024.102897
Abstrakt: The membrane proximal external region (MPER) of the HIV envelope glycoproteins has generated renewed interest after a recent phase I vaccine trial that presented MPER lipid-peptide epitopes demonstrated promise to elicit a broad neutralization response. The antigenicity of MPER is intimately associated with the membrane, and its presentation relies significantly on the lipid composition. This review brings together recent findings on the influence of membranes on the conformation of MPER and its recognition by broadly neutralizing antibodies. Specifically, the review highlights the importance of properly accounting for the balance between protein-protein and membrane-protein interactions in vaccine design.
Competing Interests: Declaration of competing interest CAL, CAD and SG declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. SMA and BFH have patents submitted covering MPER-Peptide liposome designs.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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