Sex-Dependent Effects of Cardiometabolic Health and APOE4 on Brain Age: A Longitudinal Cohort Study.

Autor:	Subramaniapillai S; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Schindler LS; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Redmond P; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Bastin ME; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Wardlaw JM; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Valdés Hernández M; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Maniega SM; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Aribisala B; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Westlye LT; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Coath W; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Groves J; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Cash DM; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Barnes J; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., James SN; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Sudre CH; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Barkhof F; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Richards M; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Corley J; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Russ TC; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Cox SR; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Schott JM; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., Cole JH; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom., de Lange AG; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psychology (L.T.W.), University of Oslo, Norway; Dementia Research Centre (W.C., J.G., D.M.C., J.B., S.-N.J., C.H.S., J.M.S.), Centre for Medical Image Computing (C.H.S., F.B., J.H.C.), and MRC Unit for Lifelong Health and Ageing (M.R., S.-N.J., C.H.S.), University College London, United Kingdom.
Jazyk:	angličtina
Zdroj:	Neurology [Neurology] 2024 Sep 24; Vol. 103 (6), pp. e209744. Date of Electronic Publication: 2024 Aug 22.
DOI:	10.1212/WNL.0000000000209744
Abstrakt:	Background and Objectives: The aging population is growing faster than all other demographic strata. With older age comes a greater risk of health conditions such as obesity and high blood pressure (BP). These cardiometabolic risk factors (CMRs) exhibit prominent sex differences in midlife and aging, yet their influence on brain health in females vs males is largely unexplored. In this study, we investigated sex differences in relationships between BP, body mass index (BMI), and brain age over time and tested for interactions with APOE ε4 genotype ( APOE4 ), a known genetic risk factor of Alzheimer disease. Methods: The sample included participants from 2 United Kingdom-based longitudinal birth cohorts, the Lothian Birth Cohort (1936) and Insight 46 (1946). Participants with MRI data from at least 1 time point were included to evaluate sex differences in associations between CMRs and brain age. The open-access software package brainageR 2.1 was used to estimate brain age for each participant. Linear mixed-effects models were used to assess the relationships between brain age, BMI, BP, and APOE4 status (i.e., carrier vs noncarrier) in males and females over time. Results: The combined sample comprised 1,120 participants (48% female) with a mean age (SD) of 73 (0.72) years in the Lothian Birth Cohort and 71 (0.68) years in Insight 46 at the time point 1 assessment. Approximately 30% of participants were APOE4 carriers. Higher systolic and diastolic BP was significantly associated with older brain age in females only (β = 0.43-0.56, p < 0.05). Among males, higher BMI was associated with older brain age across time points and APOE4 groups (β = 0.72-0.77, p < 0.05). In females, higher BMI was linked to older brain age among APOE4 noncarriers (β = 0.68-0.99, p < 0.05), whereas higher BMI was linked to younger brain age among carriers, particularly at the last time point (β = -1.75, p < 0.05). Discussion: This study indicates sex-dependent and time-dependent relationships between CMRs, APOE4 status, and brain age. Our findings highlight the necessity of sex-stratified analyses to elucidate the role of CMRs in individual aging trajectories, providing a basis for developing personalized preventive interventions.
Databáze:	MEDLINE
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