The emerging role of fat-inducing transcript 2 in endoplasmic reticulum proteostasis and lipoprotein biogenesis.
| Autor: | Brodsky JL; Department of Biological Sciences.; Center for Protein Conformational Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania., Iyer A; Department of Biological Sciences., Fortounas KI; Division of Cardiology and the Department of Medicine, NYU School of Medicine.; Cardiovascular Research Center and the Marc and Ruti Bell Program in Vascular Biology, NYU School of Medicine, New York, New York, New York, USA., Fisher EA; Division of Cardiology and the Department of Medicine, NYU School of Medicine.; Cardiovascular Research Center and the Marc and Ruti Bell Program in Vascular Biology, NYU School of Medicine, New York, New York, New York, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Current opinion in lipidology [Curr Opin Lipidol] 2024 Oct 01; Vol. 35 (5), pp. 248-252. Date of Electronic Publication: 2024 Aug 22. |
| DOI: | 10.1097/MOL.0000000000000943 |
| Abstrakt: | Purpose of Review: This review examines the evolving role of the fat-inducing transcript 2 (FIT2) protein in lipid droplet (LD) biology and its broader implications in cellular physiology and disease. With recent advancements in understanding FIT2 function across various model systems, this review provides a timely synthesis of its mechanisms and physiological significance. Recent Findings: FIT2, an endoplasmic reticulum (ER)-resident protein, has been established as a critical regulator of LD formation in diverse organisms, from yeast to mammals. It facilitates LD biogenesis by sequestering diacylglycerol (DAG) and potentially influencing ER membrane dynamics. Beyond its role in lipid metabolism, FIT2 intersects with the ER-associated degradation (ERAD), is critical for protein homeostasis, and is linked to the unfolded protein response (UPR). Dysregulation of FIT2 has also been linked to metabolic disorders such as insulin resistance and lipodystrophy, highlighting its clinical relevance. Summary: Insights into FIT2 function underscore its pivotal role in LD formation and lipid homeostasis. Understanding its involvement in ER proteostasis and very low density lipoprotein biogenesis has broad implications for metabolic diseases and cancer. Therapeutic strategies targeting FIT2 may offer novel approaches to modulate lipid metabolism and mitigate associated pathologies. Further research is needed to elucidate the full spectrum of FIT2's interactions within cellular lipid and protein networks, potentially uncovering new therapeutic avenues for metabolic and ER stress-related disorders. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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