Lymphatic System Development and Function.

Autor: Janardhan HP; Division of Cardiovascular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.; Department of Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA., Wachter BT; Division of Cardiovascular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.; Department of Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.; MD-PhD Program, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, 01605, USA., Trivedi CM; Division of Cardiovascular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA. chinmay.trivedi@umassmed.edu.; Department of Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA. chinmay.trivedi@umassmed.edu.; MD-PhD Program, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, 01605, USA. chinmay.trivedi@umassmed.edu.; Department of Molecular, Cell, and Cancer Biology, UMass Chan Medical School, Worcester, MA, 01605, USA. chinmay.trivedi@umassmed.edu.
Jazyk: angličtina
Zdroj: Current cardiology reports [Curr Cardiol Rep] 2024 Nov; Vol. 26 (11), pp. 1209-1219. Date of Electronic Publication: 2024 Aug 22.
DOI: 10.1007/s11886-024-02120-8
Abstrakt: Purpose of Review: This review delves into recent advancements in understanding generalized and organ-specific lymphatic development. It emphasizes the distinct characteristics and critical anomalies that can impair lymphatic function. By exploring developmental mechanisms, the review seeks to illuminate the profound impact of lymphatic malformations on overall health and disease progression.
Recent Findings: The introduction of genome sequencing, single-cell transcriptomic analysis, and advanced imaging technologies has significantly enhanced our ability to identify and characterize developmental defects within the lymphatic system. As a result, a wide range of lymphatic anomalies have been uncovered, spanning from congenital abnormalities present at birth to conditions that can become life-threatening in adulthood. Additionally, recent research highlights the heterogeneity of lymphatics, revealing organ-specific developmental pathways, unique molecular markers, and specialized physiological functions specific to each organ. A deeper understanding of the unique characteristics of lymphatic cell populations in an organ-specific context is essential for guiding future research into lymphatic disease processes. An integrated approach to translational research could revolutionize personalized medicine, where treatments are precisely tailored to individual lymphatic profiles, enhancing effectiveness and minimizing side effects.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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