Central Retinal Thickness Variability as a Predictive Factor for Visual Acuity After Dexamethasone Implant in Retinal Vein Occlusion.
| Autor: | Daugirdas SP, Maatouk CM, Lai HJ, Ogidigben MJ, Singh RP |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Ophthalmic surgery, lasers & imaging retina [Ophthalmic Surg Lasers Imaging Retina] 2024 Dec; Vol. 55 (12), pp. 722-729. Date of Electronic Publication: 2024 Aug 01. |
| DOI: | 10.3928/23258160-20240621-04 |
| Abstrakt: | Background and Objective: Investigate central retinal thickness (CRT) variability and changes in best-corrected visual acuity (BCVA) after 12 months in patients with retinal vein occlusion (RVO) treated with dexamethasone intravitreal implants. Patients and Methods: Post hoc analyses of two randomized trials in patients with macular edema associated with branch or central RVO treated with a 0.7-mg dexamethasone implant. Central retinal thickness standard deviation (CRT-SD) and central retinal thickness amplitude (CRT-A) were measures of variability. Analyses included multinomial and simple linear regression. Results: In 400 patients, CRT-SD and CRT-A were significantly associated with central RVO, second dexamethasone implant, and baseline CRT. Baseline BCVA was associated with CRT-A. CRT-SD and CRT-A were significantly correlated with a 12-month change in BCVA (effect sizes of -0.032 and -0.013 letters/µm; P < 0.001). Patients in the highest CRT-SD quartile gained significantly fewer letters (+1.88 letters; 95% CI: -0.46 to 4.23). Conclusion: Greater CRT variability was associated with smaller BCVA improvements in patients with RVO treated with dexamethasone implants. [ Ophthalmic Surg Lasers Imaging Retina 2024;55:722-729.] . Competing Interests: Disclosure: HJL is a consultant for AbbVie and may hold stock or stock options for AbbVie. MJO is a consultant for AbbVie and may hold stock or stock options for AbbVie. RPS is a consultant for Apellis, Eyepoint, Genentech, Bausch + Lomb, Regeneron, Abbvie, Alcon, and Biogen. The remaining authors have disclosed no potential conflicts of interest, financial or otherwise. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|