Trajectories of behavior and social cognition in behavioral variant frontotemporal dementia and primary psychiatric disorders: A call for better operationalization of socioemotional changes.

Autor:	Fieldhouse JLP; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., van Engelen ME; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., Handgraaf D; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., de Boer SCM; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., van 't Hooft JJ; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., Schouws SNTM; Department of Psychiatry, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; GGZ inGeest Mental Health Care, Amsterdam, the Netherlands., van Grootheest D; Department of Psychiatry, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; GGZ inGeest Mental Health Care, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep, and Stress, Amsterdam, the Netherlands., Kerssens C; Department of Psychiatry, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; GGZ inGeest Mental Health Care, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep, and Stress, Amsterdam, the Netherlands., Duits FH; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., van Harten AC; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., Oudega ML; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands.; Department of Psychiatry, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; GGZ inGeest Mental Health Care, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep, and Stress, Amsterdam, the Netherlands., Vijverberg EGB; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., Pijnenburg YAL; Department of Neurology, Alzheimer Center Amsterdam, Amsterdam University Medical Center, location Vrije Universiteit Medical Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands.
Jazyk:	angličtina
Zdroj:	European journal of neurology [Eur J Neurol] 2024 Dec; Vol. 31 (12), pp. e16426. Date of Electronic Publication: 2024 Aug 22.
DOI:	10.1111/ene.16426
Abstrakt:	Background and Purpose: Behavioral variant frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPD), such as mood, psychotic, and autism spectrum disorders, share similar clinical characteristics of behavior and social cognition. Better understanding of clinical progression in bvFTD and PPD is essential for adequate disease monitoring and trial design. Methods: In this longitudinal study (N = 89), patients with bvFTD and PPD with at least one follow-up assessment were included from the Social Brain Project of the Alzheimer Center Amsterdam. Behavioral change and social cognitive decline were assessed via informant-rated questionnaires (Cambridge Behavioral Inventory-Revised, Frontal Behavioral Inventory [FBI], Stereotypy Rating Inventory, Frontotemporal Dementia Rating Scale, Revised Self-Monitoring Scale [RSMS]-caregiver) and patient assessment (Ekman 60-Faces Test, RSMS-patient, Emotional Contagion Scale). Clinical trajectories (median = 1.4 years, interquartile range = 1.0-2.2) were examined using linear mixed models. In a subsample, associations with baseline serum neurofilament light (sNfL) were examined. Results: At baseline, behavioral and social cognitive symptoms were similar between diagnosis groups, except for poorer emotion recognition in bvFTD. Over time, behavioral symptoms worsened in bvFTD, whereas most measures remained stable and the FBI improved in PPD. Regarding social cognition, emotion recognition and caregiver-reported socioemotional sensitivity worsened in bvFTD and remained stable in PPD. Patient-reported social cognitive measures did not change over time. Higher sNfL was associated with faster behavioral change. Conclusions: Trajectories of behavior and social cognition differentiate bvFTD from PPD, provided that social cognition is not patient-reported. Therefore, we stress the need to optimize longitudinal social cognitive assessment in bvFTD. sNfL may be a useful prognostic marker of behavioral progression in neuropsychiatric populations. (© 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text