Serum concentration of ferroportin in women of reproductive age.

Autor:	Ćuk A; Department of Laboratory Diagnostics, Clinical Hospital Centre Mostar, Mostar, Bosnia and Herzegovina.; School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina., Rumora L; Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia., Mikulić I; Department of Laboratory Diagnostics, Clinical Hospital Centre Mostar, Mostar, Bosnia and Herzegovina.; School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina., Penava N; Department of Obstetrics and Gynecology, Clinical Hospital Centre Mostar, Mostar, Bosnia and Herzegovina., Cvetković I; Department of Laboratory Diagnostics, Clinical Hospital Centre Mostar, Mostar, Bosnia and Herzegovina.; School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina., Pušić A; Department of Laboratory Diagnostics, Clinical Hospital Centre Mostar, Mostar, Bosnia and Herzegovina.; School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina., Mikulić V; Department of Laboratory Diagnostics, Clinical Hospital Centre Mostar, Mostar, Bosnia and Herzegovina.; School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina., Ljubić K; Department of Laboratory Diagnostics, Clinical Hospital Centre Mostar, Mostar, Bosnia and Herzegovina.; School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina., Tomić V; Department of Obstetrics and Gynecology, Clinical Hospital Centre Mostar, Mostar, Bosnia and Herzegovina.
Jazyk:	angličtina
Zdroj:	Biochemia medica [Biochem Med (Zagreb)] 2024 Oct 15; Vol. 34 (3), pp. 030701. Date of Electronic Publication: 2024 Aug 05.
DOI:	10.11613/BM.2024.030701
Abstrakt:	Introduction: Ferroportin (Fpn) is the only known iron exporter and plays an essential role in iron homeostasis. Serum concentrations of Fpn in health and/or diseased states are still mostly unknown. Therefore, the aim of this study was to determine the concentration of Fpn in the serum of women of reproductive age (WRA) for the first time, and to establish whether there is a difference in the concentration of Fpn according to ferritin status. Materials and Methods: This research included 100 WRA (18-45 years, C-reactive protein (CRP) < 5 mg/L, hemoglobin > 120 g/L). Serum Fpn was measured using Enzyme Linked Immunosorbent Assay (ELISA) method on the analyzer EZ Read 800 Plus (Biochrom, Cambridge, UK). Reference interval was calculated using the robust method. Results: The median concentration of Fpn in the whole study group was 9.74 (5.84-15.69) µg/L. The subgroup with ferritin concentration > 15 µg/L had a median Fpn concentration 15.21 (10.34-21.93) µg/L, which significantly differed from Fpn concentration in the subgroup with ferritin concentration ≤ 15 µg/L (5.93 (4.84-8.36) µg/L, P < 0.001). The reference limits for the Fpn were 2.26-29.81 µg/L with 90% confidence intervals (CI) of 1.78 to 2.83 and 25.37 to 34.33, respectively. Conclusions: The proposed reference interval could help in the future research on iron homeostasis both in physiological conditions and in various disorders, because this is the first study that measured Fpn concentration in a certain gender and age group of a healthy population. Competing Interests: Potential conflict of interest None declared. (Croatian Society of Medical Biochemistry and Laboratory Medicine.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu