Exploring white matter microstructural alterations in mild cognitive impairment: a multimodal diffusion MRI investigation utilizing diffusion kurtosis and free-water imaging.

Autor:	Nelson MR; Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States.; School of Life Sciences, Arizona State University, Tempe, AZ, United States., Keeling EG; Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States.; School of Life Sciences, Arizona State University, Tempe, AZ, United States., Stokes AM; Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States., Bergamino M; Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2024 Aug 07; Vol. 18, pp. 1440653. Date of Electronic Publication: 2024 Aug 07 (Print Publication: 2024).
DOI:	10.3389/fnins.2024.1440653
Abstrakt:	Background: Mild Cognitive Impairment (MCI) is a transitional stage from normal aging to dementia, characterized by noticeable changes in cognitive function that do not significantly impact daily life. Diffusion MRI (dMRI) plays a crucial role in understanding MCI by assessing white matter integrity and revealing early signs of axonal degeneration and myelin breakdown before cognitive symptoms appear. Methods: This study utilized the Alzheimer's Disease Neuroimaging Initiative (ADNI) database to compare white matter microstructure in individuals with MCI to cognitively normal (CN) individuals, employing advanced dMRI techniques such as diffusion kurtosis imaging (DKI), mean signal diffusion kurtosis imaging (MSDKI), and free water imaging (FWI). Results: Analyzing data from 55 CN subjects and 46 individuals with MCI, this study found significant differences in white matter integrity, particularly in free water levels and kurtosis values, suggesting neuroinflammatory responses and microstructural integrity disruption in MCI. Moreover, negative correlations between Mini-Mental State Examination (MMSE) scores and free water levels in the brain within the MCI group point to the potential of these measures as early biomarkers for cognitive impairment. Conclusion: In conclusion, this study demonstrates how a multimodal advanced diffusion imaging approach can uncover early microstructural changes in MCI, offering insights into the neurobiological mechanisms behind cognitive decline. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Nelson, Keeling, Stokes and Bergamino.)
Databáze:	MEDLINE
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