Concurrent high risk HPV35, HPV45, and HPV59 infections in prostate and bladder cancer tissues of a single patient: A case report.

Autor:	Ahmed MY; School of Life Science, Pharmacy and Chemistry, Kingston University London, London, KT1 2EE, UK., Cakir MO; School of Life Science, Pharmacy and Chemistry, Kingston University London, London, KT1 2EE, UK., Salman NA; School of Life Science, Pharmacy and Chemistry, Kingston University London, London, KT1 2EE, UK., Sandhu S; Department of Urology and Surgery, Kingston Hospital, Kingston Upon Thames, London, KT2 7QB, UK., Ashrafi GH; School of Life Science, Pharmacy and Chemistry, Kingston University London, London, KT1 2EE, UK.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2024 Jul 24; Vol. 10 (15), pp. e35074. Date of Electronic Publication: 2024 Jul 24 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2024.e35074
Abstrakt:	Human papillomavirus (HPV) infections, primarily transmitted through sexual contact, have been linked to various cancers, including cervical, penile, anal, oropharynx, breast, and prostate cancers. This study presents a unique case of concurrent high-risk HPV35, HPV45, and HPV59 infections in both prostate and bladder cancer tissues from a single patient, representing the first documented instance worldwide with identical HPV types detected in two adjacent organs of the same individual. Employing a multiplex-PCR approach, gel electrophoresis, and Sanger sequencing, we confirmed the presence of these high-risk HPV types. Additionally, Western blot analysis using an HPV E7 antibody demonstrated the active expression of HPV oncoproteins in both cancer types. This discovery underscores the potential for HPV intra-organ transmission and necessitates further exploration of alternative transmission routes. The implications of our results offer new insights into the complex dynamics of HPV transmission in cancer pathogenesis. In conclusion our study reveals concurrent HPV infections in both prostate and bladder cancers within a single patient and highlights the potential intra-organ spread of HPV and the need for further investigation of alternative transmission routes. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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