Inhibitory effects of extracts from Eucalyptus gunnii on α-synuclein amyloid fibrils.

Autor:	So M; Graduate School of Agriculture, Kyoto University, Kyoto, Japan.; Institute for Protein Research, Osaka University, Osaka, Japan., Ono M; Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan., Oogai S; Saga Food & Cosmetic Laboratory, Saga Prefectural Industrial Innovation Center, Saga, Japan., Kondo M; ARFS, Hamamatsu University School of Medicine, Shizuoka, Japan., Yamazaki K; Saga Food & Cosmetic Laboratory, Saga Prefectural Industrial Innovation Center, Saga, Japan., Nachtegael C; Interuniversity Institute of Bioinformatics in Brussels, Université Libre de Bruxelles-Vrije Universiteit Brussel, Brussels, Belgium.; Machine Learning Group, Université Libre de Bruxelles, Brussels, Belgium., Hamajima H; Saga Food & Cosmetic Laboratory, Saga Prefectural Industrial Innovation Center, Saga, Japan., Mutoh R; Department of Applied Physics, Faculty of Science, Fukuoka University, Fukuoka, Japan., Kato M; Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.; Graduate School of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan., Kawate H; Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.; Graduate School of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan., Oki T; Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.; Graduate School of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan., Kawata Y; Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Tottori, Japan., Kumamoto S; Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan., Tokui N; Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.; Graduate School of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.; Institute of Preventive and Medical Dietetics, Nakamura Gakuen University, Fukuoka, Japan., Takei T; Institute for Protein Research, Osaka University, Osaka, Japan., Shimizu K; Department of Agro-Environmental Sciences, Kyushu University, Fukuoka, Japan., Inoue A; Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Yamamoto N; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Unoki M; Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Tanabe K; Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.; Graduate School of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.; Institute of Preventive and Medical Dietetics, Nakamura Gakuen University, Fukuoka, Japan., Nakashima K; Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Sasaki H; Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Hojo H; Institute for Protein Research, Osaka University, Osaka, Japan., Nagata Y; Saga Food & Cosmetic Laboratory, Saga Prefectural Industrial Innovation Center, Saga, Japan., Suetake I; Institute for Protein Research, Osaka University, Osaka, Japan.; Department of Nutritional Sciences, Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.; Graduate School of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.; Institute of Preventive and Medical Dietetics, Nakamura Gakuen University, Fukuoka, Japan.; Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Jazyk:	angličtina
Zdroj:	Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2024 Oct 22; Vol. 88 (11), pp. 1289-1298.
DOI:	10.1093/bbb/zbae114
Abstrakt:	Amyloid fibril formation is associated with various amyloidoses, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Despite the numerous studies on the inhibition of amyloid formation, the prevention and treatment of a majority of amyloid-related disorders are still challenging. In this study, we investigated the effects of various plant extracts on amyloid formation of α-synuclein. We found that the extracts from Eucalyptus gunnii are able to inhibit amyloid formation, and to disaggregate preformed fibrils, in vitro. The extract itself did not lead to cell damage. In the extract, miquelianin, which is a glycosylated form of quercetin and has been detected in the plasma and the brain, was identified and assessed to have a moderate inhibitory activity, compared to the effects of ellagic acid and quercetin, which are strong inhibitors for amyloid formation. The properties of miquelianin provide insights into the mechanisms controlling the assembly of α-synuclein in the brain. (© The Author(s) 2024. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.)
Databáze:	MEDLINE
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